The effects of rutin on a passive avoidance test in rats.

Various synthetic derivatives of natural flavonoids are known to have neuroactive properties. The aim of the present study was to investigate the effects of rutin (3, 3', 4', 5, 7-pentahydroxyflavone-3-rhamnoglucoside), a flavonoid that is an important dietary constituent of foods and plant-based beverages, on memory retrieval in rats. To this end, we assessed the effect of rutin on memory retrieval using a step-through passive avoidance task.

Antiandrogenic activities of Glycyrrhiza glabra in male rats.

Abnormal levels of androgens cause many diseases like benign prostatic hyperplasia and hormone dependent cancers. Although the reduction in serum testosterone (T) by Glycyrrhiza glabra has been reported, its effects on seminal vesicle (SV) and prostate tissues have never been reported. This study was carried out to investigate different aspects of antiandrogenic properties of this plant.

Effects of Urtica dioica extract on lipid profile in hypercholesterolemic rats.

Objective: To investigate the effects of extract of Urtica dioica, a perennial herb in Iran, on lipid profile in hypercholesterolemic rats.

Methods: The effects of Urtica dioica extract were tested by using it as a supplement in a high-cholesterol diet. Male rats were fed a high cholesterol diet (10 mL/kg) for 4 weeks with Urtica dioica extract (100 or 300 mg/kg) or 10 mg/kg lovastatin supplementation to study the hypocholesterolemic effects of Urtica dioica on plasma lipid levels, hepatic enzymes activities, and liver histopathological changes.

Effects of rutin on lipid profile in hypercholesterolaemic rats.

Rutin (3, 3', 4', 5, 7-pentahydrohyflavone-3-rhamnoglucoside) is a flavonoid of the flavonol type. Rutin is found in many plants and is also an important dietary constituent of food and plant-based beverages. Rutin has several pharmacological properties including antioxidant and cardioprotective activities.

Possible role of GABAA-benzodiazepine receptor in anticonvulsant effects of Pasipay in rats.

Objective: To investigate the anticonvulsant effects of Pasipay, a commercially available preparation of hydro-alcoholic extract of Passiflora incarnata in rats.

Methods: The anticonvulsant effects of hydro-alcoholic extract of P. incarnata, Pasipay, were observed by intracerebroventricular injection of 0.

Antiepileptic effects of quinine in the pentylenetetrazole model of seizure.

Quinine, is an anti-malarial drug that specifically blocks connexin 36 (Cx36) at gap junction channels. Quinine has suppressed ictal epileptiform activity in vitro without decreasing neuronal excitability. Thus, we considered the possible anticonvulsant effects of quinine in the pentylenetetrazole (PTZ) model of seizure.

The inhibitory effect of trimethylamine on the anticonvulsant activities of quinine in the pentylenetetrazole model in rats.

Quinine specifically blocks connexin 36 (Cx36), one of the proteins that form gap junction channels. Quinine suppressed ictal epileptiform activity in in vitro and in vivo studies without decreasing neuronal excitability. In this study, we considered the possible mechanism of anticonvulsant effects of quinine (1, 250, 500, 1000 and 2000 microM, i.

Anticonvulsive effects of intracerebroventricular administration of rutin in rats.

Various synthetic derivatives of natural flavonoids are known to have neuroactive properties. The aim of the present study was to investigate the anticonvulsant effects of rutin (3, 3', 4', 5, 7-pentahydrohyflavone-3-rhamnoglucoside), a flavonoid which is an important dietary constituent of food and plant-based beverages. To this end, we assessed the anticonvulsant effects of rutin in rats treated with pentylenetetrazole (PTZ) (90 mg/kg, i.

Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors.

Background: Passion flower (Passiflora incarnata) is used in traditional medicine of Europe and South America to treat anxiety, insomnia and seizure. Recently, it has shown antianxiety and sedative effects in human.

Methods: In this study, anticonvulsant effects of hydro- alcoholic extract of Passiflora, Pasipay, were examined by using pentylentetrazole model (PTZ) on mice.