The Application of Stress Modifiers as an Eco-Friendly Approach to Alleviate the Water Scarcity in Ajwain ( L.) Plants.

Stress modifiers are recognized as biostimulants providing beneficial effects on various plant species. However, the specific potential of modulators such as melatonin, chitosan, humic acid, and selenium in enhancing the resistance of ajwain ( L.) plants to water scarcity remains an open question.

Novel mutation in efflux pump Rv1258c (Tap) gene in drug resistant clinical isolates of Mycobacterium tuberculosis in Iran.

Introduction: Tuberculosis (TB) remains a serious public health problem worldwide. Drug-resistant TB is considered a major and growing global threat. Despite the great variety of described mutations in Mycobacterium tuberculosis (MTB) resistance genes, the mechanisms of drug resistance are still controversial.

Global groundwater droughts are more severe than they appear in hydrological models: An investigation through a Bayesian merging of GRACE and GRACE-FO data with a water balance model.

Realistic representation of hydrological drought events is increasingly important in world facing decreased freshwater availability. Index-based drought monitoring systems are often adopted to represent the evolution and distribution of hydrological droughts, which mainly rely on hydrological model simulations to compute these indices. Recent studies, however, indicate that model derived water storage estimates might have difficulties in adequately representing reality.

The Expression of miR-34c-5p Induces G0/G1 Cell Cycle Arrest and Apoptosis in SW480 Colon Cancer Cell.

Background: Expression of the miR-34 family, including miR-34a/b/c, has been reported to inhibit the progression of several cancer types by inhibiting cell proliferation and inducing apoptosis.

Objectives: We attempted to investigate the effect of SW480 cell transfection with miR-34c-5p mimics on cell proliferation.

Methods: To do this, SW480 colon cancer cell line was transfected with miR-34c-5p mimics, scramble sequence, and the vehicle in PBS mock, and then cell proliferation was assessed by MTT assay.

Predicting global thermospheric neutral density during periods with high geomagnetic activity.

Estimating global and multi-level Thermosphere Neutral Density (TND) is important for studying coupling processes within the upper atmosphere, and for applications like orbit prediction. Models are applied for predicting TND changes, however, their performance can be improved by accounting for the simplicity of model structure and the sampling limitations of model inputs. In this study, a simultaneous Calibration and Data Assimilation (C/DA) algorithm is applied to integrate freely available CHAMP, GRACE, and Swarm derived TND measurements into the NRLMSISE-00 model.

Response Surface Methodology to Optimize the Expression Efficiency of Recombinant Reteplase.

Background: Over expression of Reteplase enzyme has already been studies in the periplasmic space of (). However, the role different factors in its expresssin rate remained to be elucidated.

Objectives: Optical cell density (OD), IPTG concentration, and expression time are highly effective in the protein expression rates.

Emergency burn education: Evaluating a surgical simulation-based intervention.

Introduction: Medical simulation has provided favorable outcomes in the improvement of clinical competence at both the undergraduate and postgraduate levels. The recall of information demonstrably increases when it has been taught in environments similar to the workplace. This study aimed to evaluate the role of a one-day burn simulation session in improving students' knowledge of burn management and interest in plastic surgery as a specialty.

Evolution of 4π-Periodic Supercurrent in the Presence of an In-Plane Magnetic Field.

In the presence of a 4π-periodic contribution to the current phase relation, for example in topological Josephson junctions, odd Shapiro steps are expected to be missing. While missing odd Shapiro steps have been observed in several material systems and interpreted in the context of topological superconductivity, they have also been observed in topologically trivial junctions. Here, we study the evolution of such trivial missing odd Shapiro steps in Al-InAs junctions in the presence of an in-plane magnetic field .

Impact of 24-epibrassinolide, spermine, and silicon on plant growth, antioxidant defense systems, and osmolyte accumulation of maize under water stress.

The effect of triad application of the phytohormone 24-epibrassinolide (EBL), the polyamine spermine (Spm), and the element silicon (Si) has not yet been considered on plant growth and behavior in water-stressed conditions. We aimed to evaluate the impact of single/dual/triad application of 24-epibrassinolide (EBL), spermine (Spm), and silicon (Si) on the growth, photosynthetic metabolites, and antioxidant enzymes in the maize plant exposed to water stress. This study was conducted as a potential drought resistance system and plants' maintenance against oxidative damage.

Lymphoedema conditions disrupt endothelial barrier function .

Lymphatic vessel contractions generate net antegrade pulsatile lymph flow. By contrast, impaired lymphatic vessels are often associated with lymphoedema and altered lymph flow. The effect of lymphoedema on the lymph flow field and endothelium is not completely known.

Metabolic derangement in patients with vitiligo: a cross-sectional study.

Vitiligo is a pigmentary disorder resulting from progressive destruction of melanocytes in the skin. There is a growing body of evidence about higher risk of metabolic syndrome and dyslipidemia in some dermatoses including vitiligo. We aimed to evaluate lipid profile, leptin and C reactive protein (CRP) status among Iranian patients with vitiligo, compared with healthy controls and perused the relationship between abnormal values of these parameters with disease duration and physical characteristics of patients.

Assessment of an Articulating Laparoscopic Needle Holder (FlexDex™) Compared to a Conventional Rigid Needle Holder in 2-Dimension Vision Amongst Novices: A Randomised Controlled Study.

Aim: This study aims to compare novice performance of advanced bimanual laparoscopic skills using an articulating laparoscopic device (FlexDex™) compared to a standard rigid needle holder amongst surgical novices in 2-dimension (2D) visualisation.

Methods: In this prospective randomised trial, novices (n = 40) without laparoscopic experience were recruited and randomised into two groups, which used either traditional rigid needle holders or the FlexDex™. Both groups performed 10 repetitions of a validated assessment task.

Forecasting global and multi-level thermospheric neutral density and ionospheric electron content by tuning models against satellite-based accelerometer measurements.

Global estimation of thermospheric neutral density (TND) on various altitudes is important for geodetic and space weather applications. This is typically provided by models, however, the quality of these models is limited due to their imperfect structure and the sensitivity of their parameters to the calibration period. Here, we present an ensemble Kalman filter (EnKF)-based calibration and data assimilation (C/DA) technique that updates the model's states and simultaneously calibrates its key parameters.

Processing and Quality Control of Masks: A Review.

It is clear that viruses, especially COVID-19, can cause infection and injure the human body. These viruses can transfer in different ways, such as in air transfer, which face masks can prevent and reduce. Face masks can protect humans through their filtration function.

Naringenin enhances anti-proliferation effect of 1-ferrocenyl-3-(4-methylsulfonylphenyl) propen-1-one on two different cells via targeting calmodulin signaling pathway.

Background: FMSP is a synthesized ferrocene derivative with anti-cancer characteristics on tumor cells. Naringenin is a polyphenolic flavonoid with anti-tumor ability.

Methods: Cell viability and proliferation of two cancer cells and a normal cell line after treatment with these agents were determined with MTT assay.

Evaluation of Advanced Bimanual Skills in Novices Using the Wrist-Like FlexDex™ Articulating Laparoscopic Needle Holder in 2D and 3D Vision: A Randomised Trial.

Aim: The aim of this study was to evaluate the novice performance of advanced bimanual laparoscopic skills using the articulating FlexDex laparoscopic needle holder in two-dimensional (2D) and three-dimensional (3D) visual systems.

Methods: In this prospective randomised trial, novices (n=40) without laparoscopic experience were recruited from a university cohort and randomised into two groups, which used the FlexDex and 2D or the FlexDex™ and 3D. Both groups performed 10 repetitions of a validated assessment task.

Evaluation of Cytotoxic Potentials of Novel Synthesized Chalconeferrocenyl Derivative against Melanoma and Normal Fibroblast and Its Anticancer Effect through Mitochondrial Pathway.

The treatment of melanoma is still challenging and therefore identification of novel agents is needed for its better management. Our previous study suggested that cyclooxygenase-2 (COX-2) would be a novel target for treatment of several cancers. In the present study, we searched selective cytotoxicity and mitochondria mediated apoptosis of novel synthesized chalconeferrocenyl derivative (1-Ferrocenyl-3-(dimethylamino)-3-(4-methylsulfonylphenyl) propan-1-one) (FDMPO) as a COX-2 inhibitor on normal and melanoma cells and their mitochondria.

Significance of the coexistence of non-codon 315 katG, inhA, and oxyR-ahpC intergenic gene mutations among isoniazid-resistant and multidrug-resistant isolates of Mycobacterium tuberculosis: a report of novel mutations.

Tuberculosis (TB) is a global threat due to the emergence and spread of drug-resistant (MTB). Isoniazid (INH) is the main antibiotic used for prevention and treatment of TB. Evidence shows that accumulated mutations can produce INH resistant (INHR) strains, resulting in the progression of multidrug-resistant (MDR) TB.

Coupling hemodynamics with mechanobiology in patient-specific computational models of ascending thoracic aortic aneurysms.

Background And Objective: The prevention of ascending thoracic aortic aneurysms (ATAAs), which affect thousands of persons every year worldwide, remains a major issue. ATAAs may be caused by anything that weakens the aortic wall. Altered hemodynamics, which concerns a majority of patients with bicuspid aortic valves, has been shown to be related to such weakening and to contribute to ATAA development and progression.

Patient-specific computational evaluation of stiffness distribution in ascending thoracic aortic aneurysm.

Quantifying local aortic stiffness properties in vivo is acknowledged as essential to assess the severity of an ascending thoracic aortic aneurysm (ATAA). Recently, the LESI (local extensional stiffness identification) methodology has been established to quantify non-invasively local stiffness properties of ATAAs using electrocardiographic-gated computed tomography (ECG-gated CT) scans. The aim of the current study was to determine the most sensitive markers of local ATAA stiffness estimation with the hypothesis that direct measures of local ATAA stiffness could better detect the high-risk patients.

Effects of biofertilizers and iron nano-oxide on maize yield and physiological properties under optimal irrigation and drought stress conditions.

In this research, effects iron nano-oxide and biofertilizers and chemical was investigated on the yield and some traits of Maize under normal and drought stress conditions in two years (2018 and 2019). The experiment was performed in the form of split-spilt plot in a complete random block design with three replications. The studied irrigation treatment included three levels (normal, 85% and 65% optimum water requirement) in the main plots and iron nano-oxide at four levels (0, 0.

An overview of filtration efficiency through the masks: Mechanisms of the aerosols penetration.

The masks have always been mentioned as an effective tool against environmental threats. They are considered as protective equipment to preserve the respiratory system against the non-desirable air droplets and aerosols such as the viral or pollution particles. The aerosols can be pollution existence in the air, or the infectious airborne viruses initiated from the sneezing, coughing of the infected people.

A Ferrocene Derivative Reduces Cisplatin Resistance in Breast Cancer Cells through Suppression of MDR-1 Expression and Modulation of JAK2/STAT3 Signaling Pathway.

Background: Breast cancer is the most common kind of cancer among women in the world. Despite major cancer therapy successes in recent years, cancer cells usually develop mechanisms to survive chemotherapy- induced cell death. Therefore, new strategies are needed to reverse cancer chemoresistance.

Deciphering ascending thoracic aortic aneurysm hemodynamics in relation to biomechanical properties.

The degeneration of the arterial wall at the basis of the ascending thoracic aortic aneurysm (ATAA) is a complex multifactorial process, which may lead to clinical complications and, ultimately, death. Individual genetic, biological or hemodynamic factors are inadequate to explain the heterogeneity of ATAA development/progression mechanisms, thus stimulating the analysis of their complex interplay. Here the disruption of the hemodynamic environment in the ATAA is investigated integrating patient-specific computational hemodynamics, CT-based in vivo estimation of local aortic stiffness and advanced fluid mechanics methods of analysis.

Abundance and distribution of beach litter with acutely toxic metal concentrations.

We determined if colour, category (e.g., food packaging) or intertidal activity could explain the occurrence of litter with acute levels of metals.