Citral Protects Human Endothelial Cells Against Hydrogen Peroxide-induced Oxidative Stress.

Objectives: Oxidative stress plays a major role in endothelial dysfunction. Citral is a monoterpene aldehyde with antioxidant properties. This study aimed to investigate the effect of citral on human umbilical vein endothelial cells (HUVECs) under hydrogen peroxide (HO)-induced oxidative stress.

Sal-Like Protein 4 Transcription Factor: A Significant Diagnostic Biomarker Involved in Childhood ALL Resistance and Relapse.

Purpose: () is a stem cell transcription factor that plays an essential role in the maintenance and self-renewal of embryonic and hematopoietic stem cells, functioning as an oncogene in several cancers. However, the role of in the biological behavior of childhood acute lymphoblastic leukemia and its relationship with multidrug resistance and relapse has remained largely unknown.

Patients And Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to characterize the expression pattern of in the bone marrow samples of 43 patients with Philadelphia negative ALL and 18 children in the non-cancer control group.