Association of GST gene polymorphism and noise-induced hearing loss: GST gene polymorphism and NIHL.

Background: It has been proposed that Noise-induced hearing loss is a complex disease that is combination of environmental and genetic factors. There are inconsistent results concerning the association between variation in glutathione S-transferase () genetic polymorphisms ( rs1049055 and rs10712361) and susceptibility to Noise-induced hearing loss.

Objective: This study was designed to assess the association between gene polymorphism and Noise-induced hearing loss among noise-exposed workers.

Relationship of the MTHFD1 (rs2236225), eNOS (rs1799983), CBS (rs2850144) and ACE (rs4343) gene polymorphisms in a population of Iranian pediatric patients with congenital heart defects.

Congenital heart defects are structural cardiovascular malformations that arise from abnormal formation of the heart or major blood vessels during the fetal period. To investigate the association of 4 single nucleotide polymorphisms (SNPs) in the MTHFD1, eNOS, CBS and ACE genes, we evaluated their relationship with CHD in Iranian patients. In this case-control study, a total of 102 children with CHD and 98 control children were enrolled.