Custom-made Implants for Chronic In Vivo Electrophysiological Recording From Primate's Brain Based on the Reconstructed Skull Model.

Introduction: In vivo neural recordings from primates require the installation of implants on the skull of the animal. Despite some improvements, current routines risk predisposition to infection and failure or impose constant discomfort by placing heaviness on the top of the head.

Methods: A custom-designed imaging adapter was obtained by magnetic resonance and computerized tomography (CT) imaging of the head region.

A multimodal imaging-guided software for access to primate brains.

Background: Imaging-guided access to the brain has become a routine procedure for various research and clinical applications, including drug administration, neurophysiological recording, and sampling tissue. Therefore, open-source software is required to handle such datasets in these specific applications.

New Methods: Here, we proposed an open-source tool utilizing different imaging modalities for automating the steps to access the brain.

Psychological Correlates of Health anxiety in Response to the Coronavirus (COVID-19) Pandemic: a Cross-Sectional Online Study in Iran.

Current models suggest health anxiety as a fundamental variable associated with fear and anxiety related to COVID-19. The investigation was carried out in separate two studies on the Iranian population. The first study aims to test the COVID-19 Anxiety Inventory ( = 202).

Intranasal insulin improves the structure-function of the brain mitochondrial ATP-sensitive Ca activated potassium channel and respiratory chain activities under diabetic conditions.

Although it is well established that diabetes impairs mitochondrial respiratory chain activity, little is known of the effects of intranasal insulin (INI) on the mitochondrial respiratory chain and structure-function of mitoBK channel in diabetes. We have investigated this mechanism in an STZ-induced early type 2 diabetic model. Single ATP-sensitive mitoBK channel activity was considered in diabetic and INI-treated rats using a channel incorporated into the bilayer lipid membrane.

Electro-pharmacological profiles of two brain mitoplast anion channels: Inferences from single channel recording.

We have characterized the conduction and blocking properties of two different chloride channels from brain mitochondrial inner membranes after incorporation into planar lipid bilayers. Our experiments revealed the existence of channels with a mean conductance of 158 ± 7 and 301 ± 8 pS in asymmetrical 200 mM cis/50 mM trans KCl solutions. We determined that the channels were ten times more permeable for Cl than for K, calculated from the reversal potential using the Goldman-Hodgkin-Katz equation.