New view on the compatibility of hemoglobin function in the erythrocytes.

Objective: Aim: To study the process of hemoglobin oxidation and the enzymatic reactions associated with it.

Patients And Methods: Materials and Methods: Heparinized human blood (15 IU/ml) was obtained from the clinical department. The concentration of oxy- and methemoglobin, auto-oxidation of hemoglobin was determined spectrophotometrically spectrophotometrically.

DIABETES MELLITUS AND COVID-19: TODAY'S CHALLENGES.

Рatients with diabetes have more complications and higher mortality from COVID-19. This is due to the fact that diabetes impairs the immune response. Hyperglycemia causes a violation of the immune response, which in turn cannot control the spread of pathogenic microorganisms and therefore patients with diabetes are more susceptible to infections.

THE ROLE OF LEPTINRESISTANCE IN THE PATHOGENESIS OF OBESITY IN PREGNANT WOMEN.

Objective: The aim: To investigate the relationship between leptin resistance, lipid and carbohydrate metabolism, blood pressure in obese pregnant women.

Patients And Methods: Materials and methods: Under observation were 65 women (main group) with obesity (I degree -27 women, II degree - 24 women, III degree - 14 women) in the II trimester of pregnancy, who were hospitalized in the Department of Pathology of Pregnancy KNP «Maternity Clinical house №1 "in Lviv during 2017-2020 on preeclampsia of varying severity, which were sent for inpatient treatment by women's clinics. The control group consisted of 30 healthy pregnant women without obesity.

HISTORY OF BIOCHEMISTRY IN LVIV.

Objective: The aim: The purpose of this literature review is to shed light on the development of biochemical knowledge in the Lviv region and on prominent figures in the development of biochemistry during the Second World War.

Patients And Methods: Materials and methods: Review of literature published before 2020. We searched the literature using the search terms 'biochemists', ' Lviv National Medical University', 'second World War'.

[Profile of proinflammatory cytokines in type 1 diabetes mellitus].

The study involved 70 patients with type 1 diabetes who were under medical care in the clinical city hospital. Patients were divided into two groups: group I included patients with severe form of diabetes with complications and group II included patients without complications. The cytokine profile in the diabetes mellitus patients was investigated.

Changes in the antioxidant system and level of proinflammatory cytokin IL-1beta in the blood patients of sufferi.

Diabetes mellitus type 1 provokes the development of the oxidative stress, accompanied by the increased level of TBA-active products, activation of NO-synthases and increased production of nitric oxide. Activation of glutathione reductase, decrease of the glutathione peroxidase and superoxide dismutases activity was observed. This shows a specific disturbance in the functioning of the antioxidant defense system and the augmentation in the concentration of one of the major first line reacting cytokin (IL-1beta).

[The changes of oxidative-reductive processes and fatty acid composition of liver lipids in rats with streptozotocin-induced diabetes].

The processes of lipid peroxidation, oxidative modification of proteins, the state of antioxidant protection system enzymes and fatty acid composition of liver lipids were investigated in rats with streptosotocin-induced diabetes. The development of diabetes is accompanied by oxidative stress, which results in the activation of lipid peroxidation processes and the increase in the amount of nitrogen oxide and the activity of antioxidant protection system enzymes. The increase of the amount of saturated fatty acid and fall in the amount of unsaturated fatty acid has been detected.