Mucormycosis after CD19 chimeric antigen receptor T-cell therapy: results of a US Food and Drug Administration adverse events reporting system analysis and a review of the literature.

Chimeric antigen receptor (CAR) T-cell therapy leads to durable remissions in relapsed B-cell cancers, but treatment-associated immunocompromise leads to a substantial morbidity and mortality risk from atypical infection. Mucormycosis is an aggressive and invasive fungal infection with a mortality risk of 40-80% in patients with haematological malignancies. In this Grand Round, we report a case of mucormycosis in a 54-year-old patient undergoing CAR T-cell therapy who reached complete clinical control of Mucorales with combined aggressive surgical debridement, antifungal pharmacotherapy, and reversal of underlying risk factors, but with substantial morbidity from extensive oro-facial surgery affecting the patient's speech and swallowing.

Functional difficulties in children and youth with autism spectrum disorder: analysis of the 2019 Canadian Health Survey on Children and Youth.

Introduction: This study examined the prevalence of functional difficulties and associated factors in Canadian children/youth aged 5 to 17 years diagnosed with autism spectrum disorder (ASD).

Methods: We analyzed data from the 2019 Canadian Health Survey on Children and Youth (CHSCY), a nationally representative survey of Canadian children/youth that used the Washington Group Short Set on Functioning (WG-SS) to evaluate functioning in six daily tasks. For each functional domain, binary outcomes were derived (no/some difficulty, a lot of difficulty/no ability).

Short-term Effects of Static Stretching on Hamstring Passive Stiffness in Young and Older Women.

Objectives: The objectives of this study were to assess the acute effects of static stretching on hamstring passive stiffness in young and older women. A secondary objective was to compare hamstring muscle size and quality measurements (cross-sectional area and echo intensity) between the two groups and to determine if these characteristics are related to passive stiffness at baseline.

Methods: Fifteen young (23±4 years) and 15 older (73±5 years) women underwent two randomized conditions that included a control treatment and an experimental treatment of four, 15-s static stretches of the hamstrings.

Incidental Thyroid Tissue in Sentinel Nodes From Oral Squamous Cell Carcinoma.

Objective: Sentinel node biopsy (SNB) is a surgical staging test in which sentinel nodes (SNs) undergo intensive histological analysis. SNB diagnoses early cancer spread, but can also reveal unexpected findings within the SNs. We review cases of incidental thyroid cells (TC) found in SNs from patients with oral squamous cell carcinoma (OSCC) to assess the prevalence of TC, and the clinical significance of these.

Retrospective investigation of decreasing body temperature trends during anaesthesia in dogs.

Background: Hypothermia during the perianaesthetic period may lead to an increased risk of morbidity in veterinary patients. However, the timeline of the decrease in body temperature during general anaesthesia has been minimally investigated.

Methods: Anaesthetic records of 1097 client-owned dogs were examined.

Correcting for subcutaneous fat: Does it improve the correlation between vastus lateralis echo intensity and physical performance in older women?

Numerous studies have corrected the echo intensity of the vastus lateralis for subcutaneous fat thickness. However, it is unclear if correction for subcutaneous fat improves the correlation between vastus lateralis echo intensity and physical performance. We aimed to examine the correlations between vastus lateralis muscle morphology parameters and physical performance outcomes in older women.

An Unusual Case of Ludwig's Angina Following Mandibular Fracture.

The mandible is the most commonly fractured bone in the maxillofacial region following trauma. Severe infections are rare, and so we highlight an unusual presentation of Ludwig's angina following a late presentation of a mandibular fracture in a 68-year-old gentleman with significant medical co-morbidities. The recovery process was prolonged and involved multi-disciplinary input.

Utility of peak torque and rate of torque development characteristics to identify walking performance ability in older women.

Objectives: It is unclear whether peak torque and rate of torque development (RTD) measurements can characterize functional differences in older adults according to their performance on a six-minute walk test. This study aimed to examine the efficacy of isometric peak torque and RTD characteristics of the knee extensors to differentiate between functional status in older women who are able (higher functioning) versus those who are unable (lower functioning) to walk 550 m in six minutes.

Methods: Ten higher functioning (67±4 years) and 10 lower functioning (68±4 years) older women performed three isometric knee extension maximal voluntary contractions followed by a six-minute walk test.

The Acute Effects of Fast-Paced Walking on Isometric Peak Torque and Rate of Torque Development in Regularly Exercising and Inactive Older Women.

This study aimed to examine the acute effects of fast-paced walking on isometric peak torque and rate of torque development (RTD) in regular exercising and inactive older women. Ten regular exercising (67 ± 4 years) and 10 inactive (68 ± 4 years) older women performed three isometric knee extension contractions before and after a control condition (quiet resting) and an experimental condition of fast-paced walking for 6 min. Peak torque and early (RTD100), late (RTD200), and maximum (peak RTD) RTD measurements were obtained from each contraction.

Age-Related Differences in Hip Flexion Maximal and Rapid Strength and Rectus Femoris Muscle Size and Composition.

This study aimed to examine the effects of age on hip flexion maximal and rapid strength and rectus femoris (RF) muscle size and composition in men. Fifteen young (25 [3] y) and 15 older (73 [4] y) men performed isometric hip flexion contractions to examine peak torque and absolute and normalized rate of torque development (RTD) at time intervals of 0 to 100 and 100 to 200 milliseconds. Ultrasonography was used to examine RF muscle cross-sectional area and echo intensity.

Real-time measurement of isometric peak torque and rate of torque development using a novel strength testing device: a validity and reliability study.

: Isometric peak torque (PT) and rate of torque development (RTD) are important characteristics relevant to athletic performance. A novel device called the Dynamo Torque Analyzer calculates and displays real-time measurements of isometric PT and RTD. However, the ability of the Dynamo to provide valid and reliable isometric PT and RTD measurements similar to those of an isokinetic dynamometer remains unclear.

Impact of coronavirus disease 2019 on urgent referrals to secondary care otolaryngology: a prospective case series.

Objective: As the novel coronavirus disease 2019 changed patient presentation, this study aimed to prospectively identify these changes in a single ENT centre.

Design: A seven-week prospective case series was conducted of urgently referred patients from primary care and accident and emergency department.

Results: There was a total of 133 referrals.

Effects of age on vertical jump performance and muscle morphology characteristics in females.

Background: Declines in muscle morphology and function are commonly reported as a consequence of aging. However, few studies have investigated the influence of age on a comprehensive set of muscle function-related measures (i.e.

The time course of passive stiffness responses following an acute bout of static stretching in healthy, elderly men.

Background: The time course of passive stiffness responses following an acute bout of static stretching has received little research attention, particularly in older adults.

Objective: To determine the time course of the acute effects of static stretching on passive stiffness of the hamstrings in healthy, elderly men.

Methods: Fifteen elderly men (age = 70 ± 7 years) underwent two randomized conditions that included a control treatment and an experimental treatment of four, 15-s straight-leg raise static stretches.

Collaborative student-faculty research to support PhD research education.

This paper describes a three-semester hour applied research course taught over three semesters in a revamped PhD research curriculum at a Midwestern high research activity (R2) university-based nursing program. Faculty developed this strategy to help students become adequately prepared nurse scientists. Students and faculty engaged in a collaborative research project to provide students with opportunities to develop, integrate, and apply research knowledge, skills, and attitudes while concurrently advancing through the related research courses.

Relationships between hamstring morphological characteristics and postural balance in elderly men.

Objectives: The link between hamstring morphology and postural balance performance in older adults is not well understood. This study aimed to examine the relationships between hamstring morphological characteristics of muscle size (cross-sectional area [CSA]) and quality (echo intensity [EI]) and postural balance with the eyes open and closed in elderly men.

Methods: Nineteen healthy elderly men (age= 73±4 years) participated in this study.

The Extended Supervised Learning Event (ESLE): Assessing Nontechnical Skills in Emergency Medicine Trainees in the Workplace.

Study Objective: The contribution of emergency medicine clinicians' nontechnical skills in providing safe, high-quality care in the emergency department (ED) is well known. In 2015, the UK Royal College of Emergency Medicine introduced explicit validated descriptors of nontechnical skills needed to function effectively in the ED. A new nontechnical skills assessment tool that provided a score for 12 domains of nontechnical skills and detailed narrative feedback, the Extended Supervised Learning Event (ESLE), was introduced and was mandated as part of the Royal College of Emergency Medicine assessment schedule.

Assessment and economic valuation of air pollution impacts on human health over Europe and the United States as calculated by a multi-model ensemble in the framework of AQMEII3.

The impact of air pollution on human health and the associated external costs in Europe and the United States (US) for the year 2010 are modeled by a multi-model ensemble of regional models in the frame of the third phase of the Air Quality Modelling Evaluation International Initiative (AQMEII3). The modeled surface concentrations of O, CO, SO and PM are used as input to the Economic Valuation of Air Pollution (EVA) system to calculate the resulting health impacts and the associated external costs from each individual model. Along with a base case simulation, additional runs were performed introducing 20 % anthropogenic emission reductions both globally and regionally in Europe, North America and east Asia, as defined by the second phase of the Task Force on Hemispheric Transport of Air Pollution (TF-HTAP2).