A Comparison of Energy-Efficient Seizure Detectors for Implantable Neurostimulation Devices.

Introduction: About 30% of epilepsy patients are resistant to treatment with antiepileptic drugs, and only a minority of these are surgical candidates. A recent therapeutic approach is the application of electrical stimulation in the early phases of a seizure to interrupt its spread across the brain. To accomplish this, energy-efficient seizure detectors are required that are able to detect a seizure in its early stages.

Low-frequency electrical stimulation reduces cortical excitability in the human brain.

Effective seizure control remains challenging for about 30% of epilepsy patients who are resistant to present-day pharmacotherapy. Novel approaches that not only reduce the severity and frequency of seizures, but also have limited side effects are therefore desirable. Accordingly, various neuromodulation approaches such as cortical electrical stimulation have been implemented to reduce seizure burden; however, the underlying mechanisms are not completely understood.

Hardware Implementation of a Performance and Energy-optimized Convolutional Neural Network for Seizure Detection.

We present for the first time a μW-power convolutional neural network for seizure detection running on a low-power microcontroller. On a dataset of 22 patients a median sensitivity of 100% is achieved. With a false positive rate of 20.

A Comparison of Machine Learning Classifiers for Energy-Efficient Implementation of Seizure Detection.

The closed-loop application of electrical stimulation via chronically implanted electrodes is a novel approach to stop seizures in patients with focal-onset epilepsy. To this end, an energy efficient seizure detector that can be implemented in an implantable device is of crucial importance. In this study, we first evaluated the performance of two machine learning algorithms (Random Forest classifier and support vector machine (SVM)) by using selected time and frequency domain features with a limited need of computational resources.