Publications by authors named "Farrell S Leibovitch"
Article Synopsis
- Early identification of hemispatial neglect in acute stroke patients is crucial for nursing care, family support, and planning interventions, even though its early treatment outcomes remain unclear.
- Previous assessments often miss mild neglect or are too time-consuming for bedside use.
- The Sunnybrook Neglect Assessment Procedure (SNAP) was validated on 224 stroke patients and found to be a reliable and efficient tool for detecting neglect in acute settings.
Purpose: Quantification methods for white matter hyperintensities (WMH) on Magnetic Resonance Imaging are heterogeneous, deterring their application. This study compared three WMH rating scales, varying in complexity, and a volumetric method, to evaluate trade-offs between complexity and clinical utility in differentiating dementia subgroups and in correlating with cognition.
Methods: WMH were rated using the Fazekas, Age-Related White Matter Changes (ARWMC) and Scheltens scales, and segmented by computational volumetry in 108 patients with Alzheimer's Disease (AD), 23 with Mild Cognitive Impairment (MCI) and 34 normal controls (NC).
Patients with Alzheimer's disease (AD) display a multiplicity of cognitive deficits in domains such as memory, language, and attention, all of which can be clearly linked to the underlying neuropathological alterations. The typical degenerative changes occur early on in the disease in the temporal-parietal lobes, with other brain regions, such as the frontal cortex, becoming more affected as the disease progresses. In light of the importance of the parietal cortex in mediating visuospatial attentional processing, in the present study, we investigated a deficit in covert orienting of visual attention and its relationship to cortical hypoperfusion in AD.
View Article and Find Full Text PDFBackground: Alzheimer's Disease (AD) is frequently associated with changes in appetite. This study investigated the relationship between regional cerebral perfusion and appetite loss in AD.
Methods: 64 patients with possible or probable AD were characterized as being with (n=22) or without (n=44) appetite loss based on the Neuropsychiatric Inventory (NPI) Appetite subscale.
Background/aims: To assess the association between regional cerebral blood flow (rCBF) and apathy in Alzheimer's Disease (AD).
Methods: SPECT and MRI scans were obtained from 51 nondepressed outpatients meeting criteria for probable AD (age 77.6 +/- 6.
Background: It is not understood why some patients with Alzheimer disease (AD) display aggression and others do not.
Objective: To examine the relation between regional brain perfusion and aggression in AD.
Design: Single-photon emission computed tomographic scans were coregistered to a standardized template in Talairach space, generating mean ratios of uptake referenced to the cerebellum.