Cajanus cajan (L) Millsp seeds extract prevents rotenone-induced motor- and non-motor features of Parkinson disease in mice: Insight into mechanisms of neuroprotection.

Ethnopharmacological Relevance: Cajanus cajan (L) Millsp (Fabaceae) seed decoction is used by traditional healers in Nigeria as nerve tonic, hence, could be beneficial in the treatment of Parkinson's disease (PD), a progressive and debilitating neurodegenerative disease that imposes great burden on the healthcare system globally.

Aim Of The Study: This study aimed at investigating the neuroprotective effect of ethanol seed extract of Cajanus cajan (CC) in the treatment of rotenone-induced motor symptoms and non-motor symptoms associated with PD.

Materials And Methods: To assess the protective action of CC on rotenone-induced motor- and non-motor symptoms of PD, mice were first pretreated with CC (50, 100 or 200 mg/kg, p.

Effects of glyphosate-based herbicide on gametes fertilization and four developmental stages in Clarias .

Comparative toxicology continues to provide information on how the age of every living organism affects the frequency, severity, and nature of the potentially toxic agent. We investigated the effect of glyphosate-based herbicide (GBH) exposure on gametes and four developmental stages of Clarius gariepinus (C) (African Catfish). Gametes from healthy gravid female and mature male C were exposed to GBH in sublethal concentrations of 0.

Antibiotic utilization study in a teaching hospital in Nigeria.

Background: Antibiotics have been the bedrock of modern medical care, particularly bacterial infections. However, globally, antimicrobial resistance has become a well-recognized public health threat in recent years, and interventions to reduce its burden have been launched worldwide.

Objectives: The present study evaluated antibiotic utilization in both hospitalized patients and outpatients in a University Hospital in Nigeria.

abrogates depression- and anxiety-like disorders in mice: possible involvement of monoaminergic pathways in its antidepressant activity.

Objectives: Ethno-botanical surveys uncovered the use of in the management of mental health abnormalities. Antidepressant- and anxiolytic-like activities of hydroethanol leaf extract of (HLDS) in mice and its possible mechanism of action were investigated in this study.

Methods: The hole-board test (HBT), open field test (OFT), elevated plus maze test (EPMT), and social interaction test (SIT) were used to investigate the anxiolytic-like activity while forced swim test (FST) and tail suspension test (TST) were employed for the antidepressant effect.