The Implementation and Outcomes of Personalized Antihypertensive Therapy Based on Pharmacogenetic Testing: A Retrospective Study Examining Blood Pressure Control and Medication Tolerability.

Background: Hypertension management typically relies on standardized treatment regimens, which may not account for individual genetic variations that affect drug metabolism and response.

Objective: The objective of this study was to evaluate the effectiveness of personalized antihypertensive therapy, guided by pharmacogenetic testing, in terms of blood pressure (BP) control and medication tolerability.

Materials And Methods: A retrospective cohort study was conducted at Jinnah Postgraduate Medical Centre, Karachi, from January 2023 to December 2023.

The immunomodulatory effects of Mesenchymal stem cells on THP-1-derived macrophages against Mycobacterium tuberculosis H37Ra infection.

Background: Immune imbalance is crucial in tuberculosis pathogenesis and may be modulated by mesenchymal stem cells (MSCs). However, how MSCs regulate the host's response to Mycobacterium tuberculosis (Mtb) is unclear.

Methods: Human umbilical cord-derived MSCs were co-cultured with Mtb-infected THP-1 macrophages.

Irish Prostate Cancer Outcomes Research (IPCOR) registry: cohort profile.

Purpose: To describe the Irish Prostate Cancer Outcomes Research (IPCOR) registry. The cohort was collected to inform and improve the prostate cancer journey of men in Ireland.

Participants: Established in 2015, IPCOR was a unique large-scale prospective cohort study registering men with prostate cancer in Ireland.

Electrochemical Conversion of Biomass-Derived 5-Hydroxymethylfurfural into 2,5-Furandicarboxylic Acid by Time-Controlled Aerosol-Assisted Chemical Vapor Deposited FeNi Catalyst.

The conversion of 5-hydroxymethylfurfural (HMF) into valuable chemicals, such as 2,5-furandicarboxylic acid (FDCA), is pivotal for sustainable chemical production, offering a renewable pathway to biodegradable plastics and high-value organic compounds. This pioneering study explores the synthesis of FeNi nanostructures via aerosol-assisted chemical vapor deposition (AACVD) for the electrochemical oxidation of HMF to FDCA. By adjusting the deposition time, we developed two distinct nanostructures: FeNi-40, which features nanowires with spherical terminations, and FeNi-80, which features aggregated spherical structures.

Levofloxacin induces erythrocyte contraction leading to red cell death.

Background: Levofloxacin, a fluoroquinolone, is an extensively used antibiotic effective against both positively and negatively staining bacteria. It works by inhibiting bacterial topoisomerase type II and topoisomerase type IV, resulting in impaired DNA synthesis and bacterial cell death. Eryptosis is another term for apoptotic cell death of erythrocyte marked by cell shrinkage, phosphatidylserine (PS) flipping, and membrane blebbing.

Produced water treatment by semi-continuous sequential bioreactor and microalgae photobioreactor.

Produced water (PW) from oil and gas exploration adversely affects aquatic life and living organisms, necessitating treatment before discharge to meet effluent permissible limits. This study first used activated sludge to pretreat PW in a sequential batch reactor (SBR). The pretreated PW then entered a 13 L photobioreactor (PBR) containing Scenedesmus obliquus microalgae culture.

Epidemiology and clinical characteristics of adult patients presenting to a low resource, tertiary care emergency department in Pakistan: Challenges & Outcomes.

Objectives: Emergency Departments (EDs) play a major role in managing acute and chronic illnesses, especially in low-to-middle-income countries like Pakistan, which lacks effective primary healthcare. This study reports the epidemiology and clinical characteristics of patients presenting over a two-year period at the Indus Hospital and Health Network (IHHN) adult ED in Karachi, Pakistan.

Methods: This is a retrospective observational study conducted through chart review of 264,859 patients, aged 16 years and above, who presented to the IHHN ED, Korangi Campus, from January 2019 to December 2020 after obtaining approval from IHHN IRB.

Enhancement of paediatric oncology pharmacy practices in a low-middle-income country through teaching and training using the My Child Matters Grant.

The development of a successful oncology pharmacy system includes competency training, cost-efficient procurement, proper storage, preparation and administration of chemotherapy, and appropriate waste disposal. Low-middle-income countries such as Pakistan face several challenges within the realm of oncology pharmacy such as the unavailability of training programmes, resources and financial support, and inconsistencies in the safe handling of cytotoxic drugs. The Indus Hospital and Health Network (IHHN) is among the pioneers of oncology pharmacy practices in Pakistan, with a well-established Oncology Pharmacy Team and chemotherapy preparation in accordance with the United States Pharmacopeia 797 and 800 safety guidelines.

Clinical Outcomes Following the Implementation of a Novel One-Year Training Program in Emergency Medicine in Karachi, Pakistan.

Background: Most Emergency Departments (EDs) in low- and middle-income countries (LMICs), particularly in Pakistan, are staffed by physicians not formally trained in Emergency Medicine (EM). As of January 2022, there were only 13 residency training programs in EM throughout all of Pakistan. Therefore, an intermediate solution-a one-year training program in EM-was developed to build capacity.

Risk factors associated with higher mortality in patients with cardiac implantable electronic device infection.

Introduction: Cardiac Implantable Electronic Devices (CIEDs) are widely used for the management of advanced heart failure and ventricular arrhythmias. CIED-Infection (CIED-I) has very high mortality, especially in the subsets of patients with limited health-care access and delayed presentation. The purpose of this study is to identify the risk-predictors mortality in subjects with CIED-I.

Implementation of evidence-based psychosocial care in six pediatric oncology units across Pakistan.

Background: Despite rising childhood cancer incidence, low-middle income countries often fall short of quality resources to prioritize and develop psycho-oncology services. Patients and families suffering from cancer are subject to great psychological distress and require continuous psychosocial support. Unfortunately, a lack of mental health awareness and trained providers remains a pertinent issue in resource-strained countries such as Pakistan.

Hemoperitoneum, Hepatic Laceration, and Hepatic Artery Pseudoaneurysm as a Complication of Emergent Pericardiocentesis.

Emergent pericardiocentesis is a potentially life-saving therapeutic procedure. We report a case of hemoperitoneum, a rare but known complication of pericardiocentesis; due to hepatic artery laceration and hepatic artery pseudoaneurysm formation resulting in delayed hemorrhagic shock as a complication of emergent pericardiocentesis. ().

Assessing and Implementing Nursing Standards in Pediatric Oncology Units in a Low- to Middle-Income Country.

Oncology nurses are stakeholders in the global fight against childhood cancer. In low- to middle-income countries, the burden of care on nursing staff is high, and nurses face several unique challenges. To optimize pediatric.

Thermal transport of biological base fluid with copper and iron oxide nanoparticles in wavy channel.

The nanoparticles are frequently used in biomedical science for the treatment of diseases like cancer and these nanoparticles are injected in blood which is transported in the cardiovascular system on the principle of peristalsis. This study elaborates the effects of Lorentz force and joule heating on the peristaltic flow of copper and iron oxide suspended blood based nanofluid in a complex wavy non-uniform curved channel. The Brinkman model is utilized for the temperature dependent viscosity and thermal conductivity.

Heat Transport Exploration for Hybrid Nanoparticle (Cu, FeO)-Based Blood Flow via Tapered Complex Wavy Curved Channel with Slip Features.

Curved veins and arteries make up the human cardiovascular system, and the peristalsis process underlies the blood flowing in these ducts. The blood flow in the presence of hybrid nanoparticles through a tapered complex wavy curved channel is numerically investigated. The behavior of the blood is characterized by the Casson fluid model while the physical properties of iron (FeO) and copper (Cu) are used in the analysis.

Assessment of CO biofixation and bioenergy potential of microalga through its biomass pyrolysis, and elucidation of pyrolysis reaction kinetics modeling and artificial neural network.

This study investigates CO biofixation and pyrolytic kinetics of microalga using model-fitting and model-free methods. Microalga was grown in two different media. The highest rate of CO fixation (0.

Recent progress in microalgae-derived biochar for the treatment of textile industry wastewater.

Textile industry utilize a massive amount of dyes for coloring. The dye-containing effluent is released into wastewater along with heavy metals that are part of dye structure. The treatment of textile industry wastewater using conventional techniques (coagulation, membrane technique, electrolysis ion exchange, etc.

Achievements and pitfalls in improving Pediatric Oncology Nursing standards: A public-private partnership project.

Rationale: Approximately 8,000 new cases of pediatric cancer arise annually in Pakistan. However, there is a dire survival rate of 30-35% due to various factors, especially a lack of competent nurses in pediatric oncology care. Public-private partnerships (PPP) supported by a My Child Matters (MCM) Grant from Sanofi Espoir Foundation was granted to Indus Hospital & Health Network (IH&HN) to improve pediatric nursing standards.

Coronary Artery Aneurysms in ST-Elevation Myocardial Infarction (From a United States Based National Cohort).

This study aimed to study group differences in patients presenting with ST-elevation myocardial infarction (STEMI) based on the presence or absence of associated coronary artery aneurysms (CAA). The cause-and-effect relationship between CAAs and STEMI is largely unknown. The Nationwide Readmission database was used to identify and study group differences of patients with STEMI and with and without CAA from 2014 to 2018.

Large electromagnetic field enhancement in plasmonic nanoellipse for tunable spaser based applications.

We theoretically demonstrated a class of plasmonic coupled elliptical nanostructure for achieving a spaser or a nanolaser with high intensity. The plasmonic ellipse is made up of gold film substrate. The proposed structure is then trialed for various light polarizations, moreover, a simple elliptical nanostructure has been chosen primarily from which different cases have been formed by geometry alteration.