Purpose: This study evaluated the efficacy of short-term danazol prophylaxis in hereditary angioedema patients undergoing maxillofacial or dental procedures.
Patients And Methods: Twelve patients with a history of edema after dental procedures were administered danazol (600 mg/d) 4 days preoperatively and 4 days postoperatively. The serum levels of complement components were determined preoperatively and postoperatively as well as at 6, 12 and 24 hours in six patients.
A patient with two diseases, based presumably on different immunopathological mechanisms, hereditary angioedema (HAE) and Crohn's disease, was followed for 8 years. For more than three years of this observation period, detailed laboratory data were also available and could be analyzed. Both diseases had severe courses requiring chronic treatment with danazol and sulfasalazine, respectively.
View Article and Find Full Text PDFThe authors evaluated the efficacy of short-term danazol prophylaxis in 12 hereditary angioedema patients undergoing maxillofacial or dental procedures. Hereditary angioedema is an autosomal dominant disorder resulting from the deficiency of the C1 esterase inhibitor. Characteristic clinical manifestations include the formation of subcutaneous and submucosal edema.
View Article and Find Full Text PDFHereditary C1 esterase inhibitor deficiency is often associated with immunpathologic disorders. The authors present a case of the rare coincidence of hereditary angioedema (HAE) and Crohn's disease. The history of the patient is analysed along with the familial occurrence of the disease.
View Article and Find Full Text PDFAccording to earlier theories certain parts of a chemical wave front propagating in a 2-D excitable medium with a convex obstacle should be involutes of that obstacle. The present paper discusses a special case where self-sustained chemical waves are rotating around a central obstacle in an annular 2-D excitable region. A simple geometrical model of wave propagation based on the Fermat principle (minimum propagation time) is suggested.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
March 1969
It was recognized in Riemann's work more than one hundred years ago and proved recently by Rauch (cf. Bull. Am.
View Article and Find Full Text PDFOne of the classical tools for the study of moduli of compact Riemann surfaces is the Riemann theta function. Preliminary results were announced earlier(1) which established relations between two kinds of theta constants on a compact Riemann surface of genus 2. In this note we generalize the results there obtained.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 1968