Publications by authors named "Faris Saba"
Aims: Cartilage injuries rarely heal spontaneously and often require surgical intervention, leading to the formation of biomechanically inferior fibrous tissue. This study aimed to evaluate the possible effect of amelogenin on the healing process of a large osteochondral injury (OCI) in a rat model.
Methods: A reproducible large OCI was created in the right leg femoral trochlea of 93 rats.
Lateral ligament tears, also known as high-grade ankle sprains, are common, debilitating, and usually heal slowly. Ten to thirty percent of patients continue to suffer from chronic pain and ankle instability even after 3 to 9 months. Previously, we showed that the recombinant human amelogenin (rHAM ) induced regeneration of fully transected rat medial collateral ligament, a common proof-of-concept model.
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- GAS6, expressed by oral epithelial cells and dendritic cells, is essential for maintaining oral mucosal health and regulating immune responses against pathogens.
- The study shows that in mice lacking GAS6, the development of pathogen-specific oral immune responses is significantly impaired due to alterations in inflammatory and regulatory pathways.
- GAS6 promotes both the migration of immune cells to the oral mucosa and lymph nodes, while simultaneously downregulating pro-inflammatory signals and inhibiting dendritic cell maturation, indicating its role in balanced mucosal immunity.
Injuries to ligaments are common, painful and debilitating, causing joint instability and impaired protective proprioception sensation around the joint. Healing of torn ligaments usually fails to take place, and surgical replacement or reconstruction is required. Previously, we showed that in vivo application of the recombinant human amelogenin protein (rHAM(+)) resulted in enhanced healing of the tooth-supporting tissues.
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