Publications by authors named "Faris Madanat"
Introduction: T-cell acute lymphoblastic leukemia (T-ALL) accounts for approximately 15% of all newly diagnosed ALL in children and adolescents and is associated with worse outcomes compared to pre-B ALL. We aimed to decrease T-ALL relapses by intensifying our regimen.
Methods: Patients with T-ALL were treated using two different regimens; before September 2014, patients were treated per St.
Article Synopsis
- - A study examined how neuraminidase inhibitors (NAIs) affect the length of hospital stays for patients with influenza A(H1N1)pdm09 by analyzing data from over 18,000 individuals from 70 clinical centers.
- - Results indicated that starting NAI treatment upon hospitalization leads to a 19% decrease in length of stay compared to starting later or not at all, with consistent findings across different patient groups.
- - The study concluded that immediate NAI treatment for hospitalized influenza patients correlates with shorter hospital stays compared to delayed treatment or no treatment, regardless of when symptoms began.
Background: The impact of neuraminidase inhibitors (NAIs) on influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection.
Methods: A worldwide meta-analysis of individual participant data from 20 634 hospitalised patients with laboratory-confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) 'pandemic influenza'.
Features and outcomes of pediatric early T cell leukemia: King Hussein Cancer Center experience.
Hematol Oncol Stem Cell Ther
September 2016
Analysis of KRAS and NRAS Gene Mutations in Arab Asian Children With Acute Leukemia: High Frequency of RAS Mutations in Acute Lymphoblastic Leukemia.
Pediatr Blood Cancer
December 2015
Background: KRAS and NRAS gene mutations are frequently observed in childhood leukemia. The objective of this study was to determine the frequency of RAS mutations and the association between RAS mutations and other genetic aberrations in Arab Asian children with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML).
Methods: Diagnostic samples of 485 patients (<18 years) with acute leukemia from Iraq and Jordan were obtained, using Flinders Technology Associates filter papers.
Aberrant T-cell antigen expression in Jordanian children with B lymphoblastic leukemia.
Hematol Oncol Stem Cell Ther
December 2015
Background: RUNX1 mutation plays an important role in adult leukemic transformation. However, its contribution to the development of childhood leukemia remains unclear. In the present study, we analyzed point mutations of RUNX1 gene in children and adolescents with acute myeloid leukemia (AML) from Iraq and Jordan.
View Article and Find Full Text PDFEffectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data.
Lancet Respir Med
May 2014
Article Synopsis
- The study analyzed the effectiveness of neuraminidase inhibitors in reducing mortality among hospitalized patients with the H1N1 virus during the pandemic.
- Data from 29,234 patients across 78 studies was examined to assess the impact of these antiviral treatments.
- Results showed that neuraminidase inhibitors reduced mortality risk, particularly when administered early (within two days of symptom onset), highlighting the importance of prompt treatment.
Safety of inadvertent administration of overdose of intrathecal Cytarabine in a pediatric patient.
J Oncol Pharm Pract
October 2015
Purpose: To describe a medication error of intrathecal Cytarabine overdose that was managed conservatively with no apparent toxicities.
Summary: An 11-year-old girl was diagnosed with bone marrow relapsed precursor B-cell acute lymphoblastic leukemia. According to her chemotherapy protocol, she was started on triple intrathecal chemotherapy consisting of Methotrexate, Cytarabine and Hydrocortisone on day 1 of the protocol.
Background: Little is known about childhood ALL in the Middle East. This study was undertaken by MECCA as initial efforts in collaborative data collection to provide clinical and demographic information on children with ALL in the Middle East.
Procedure: Clinical and laboratory data for patients with ALL between January 2008 and April 2012 were prospectively collected from institutions in 14 Middle East countries and entered into a custom-built-database during induction phase.
Background: Most children with acute lymphoblastic leukemia (ALL) receive blood transfusions. Transfusions may affect ALL outcomes through transfusion-related immunomodulation (TRIM).
Methods: We analyzed overall survival (OS) and event-free survival (EFS) in relation to leukocyte reduced and irradiated (LR/IRR) blood products transfused during the induction phase in 136 children with ALL.
Background: Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) remained until recently the molecular genetic abnormality associated with the worst outcome. Hematopoietic stem cell transplant (HSCT) was considered the treatment of choice, however, recent data have indicated that chemotherapy plus tyrosine kinase inhibitor (TKI) maybe an alternative effective therapy.
Methods: We conducted a retrospective analysis of children (<18 years) with Ph+ ALL who were treated at King Hussein Cancer Center (KHCC) from January 2003 till December 2011.
Two children with acute lymphoblastic leukemia/lymphoma developed recurrent acute pancreatitis during treatment; the etiology was presumed to be secondary to 6-mercaptopurine (6MP). Both had no further attacks after discontinuation of 6MP. Acute pancreatitis secondary to 6MP is extremely rare in acute leukemia/lymphoma although it has been reported in patients with other conditions like inflammatory bowel disease; the reason for this difference is not clearly understood.
View Article and Find Full Text PDFBackground: Accurate data about childhood acute lymphoblastic leukemia (ALL) in low- and middle-income countries are lacking. Our study is designed to assess survival of childhood ALL at King Hussein Cancer Center (KHCC) using modified St. Jude Children's Research Hospital protocols.
View Article and Find Full Text PDFRetrospective analysis of pediatric cancer patients diagnosed with the pandemic H1N1 influenza infection.
Pediatr Blood Cancer
January 2011
Background: Limited data are available on disease characteristics and outcome of children with cancer who contracted the H1N1 influenza infection during the 2009 pandemic.
Methods: All 76 pediatric patients with cancer and documented H1N1 infection who presented to the Pediatric Department at King Hussein Cancer Center (KHCC) between October 1 and December 1, 2009 were reviewed for clinical characteristics and course of the disease.
Results: Two-thirds of the patients had hematological malignancies and half were receiving non-intensive chemotherapy at the time of infection.