Publications by authors named "Faris Elbahi Joatar"
Background: Ghrelin (GHRL), a gastric peptide encoded by the GHRL gene, is known to be involved in energy homeostasis via its G protein receptor, encoded by the growth hormone secretagogue receptor (GHSR) gene. Some studies have shown associations between plasma GHRL levels and GHRL single-nucleotide polymorphisms (SNPs), namely the Leu72Met polymorphism (rs696217 TG), with type 2 diabetes mellitus (T2DM) and insulin resistance (IR), while others have not. The controversies in these associations raise the issue of 'which SNPs in which populations.
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- - The study aimed to explore the connection between plasma ghrelin levels and insulin resistance (IR) in Saudi individuals with type 2 diabetes mellitus (T2DM), noting that IR is a key feature of the disease.
- - In the research, 107 T2DM patients and 101 healthy controls were analyzed for their biochemical profiles, with findings revealing that 46.7% of T2DM patients exhibited IR, and there was a notable association between low ghrelin levels and the presence of T2DM and IR.
- - The conclusions indicated a relatively low prevalence of IR in the sample and suggested that lower plasma ghrelin levels might be linked to higher IR, particularly highlighting that this trend was mostly observed