Publications by authors named "Farindira Vesti Rahmasari"
Evolution of genetic markers for drug resistance after the introduction of dihydroartemisinin-piperaquine as first-line anti-malarial treatment for uncomplicated falciparum malaria in Indonesia.
Farindira Vesti Rahmasari Puji Budi Setia Asih Ismail Ekoprayitno Rozi Suradi Wangsamuda Rifqi Risandi
Malar J
August 2023
Article Synopsis
- Dihydroartemisinin-piperaquine has been effective against uncomplicated Plasmodium falciparum malaria in Indonesia, but there's a slight increase in late treatment failures over time despite no artemisinin resistance observed.
- The research analyzed blood samples from malaria patients to investigate genetic markers for drug resistance, finding new SNPs but no SNPs linked to artemisinin resistance, and low levels of piperaquine resistance mutations.
- The findings suggest ongoing efficacy of the treatment, with most late failures attributed to reinfections rather than treatment failure, indicating that while resistance is not a major concern, continued monitoring is essential.
This review article aims to investigate the genotypic profiles of Plasmodium falciparum and Plasmodium vivax isolates collected across a wide geographic region and their association with resistance to anti-malarial drugs used in Indonesia. A systematic review was conducted between 1991 and date. Search engines, such as PubMed, Science Direct, and Google Scholar, were used for articles published in English and Indonesian to search the literature.
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