Influence of Cationic -Substituted Porphyrins on the Antimicrobial Photodynamic Efficacy and Cell Membrane Interaction in .

Photodynamic inactivation (PDI) is a non-antibiotic option for the treatment of infectious diseases. Although Gram-positive bacteria have been shown to be highly susceptible to PDI, the inactivation of Gram-negative bacteria has been more challenging due to the impermeability properties of the outer membrane. In the present study, a series of photosensitizers which contain one to four positive charges (⁻) were used to evaluate the charge influence on the PDI of a Gram-negative bacteria, (), and their interaction with the cell membrane.