The effect of simvastatin- Linn. combination on the improvement of fatty pancreas in rats induced with a high fructose and cholesterol diet.

Objective: The study aimed to determine the effect of Linn. (AI) root extract and a combination of simvastatin-AI on improving the fatty pancreas in Sprague-Dawley rats induced with a high fructose and cholesterol diet.

Materials And Methods: Twenty-four male Sprague-Dawley rats were induced with a high fructose and cholesterol diet for 4 weeks before being divided into four groups.

In-vitro antioxidant, in-vivo anti-inflammatory, and acute toxicity study of Indonesian propolis capsule from s.

Propolis is widely used as traditional medicine since ancient times. It was necessary to conduct the pre-clinical study because of its relevant curative properties. This study aimed to investigate in-vitro antioxidant, standardize quality parameters, study acute toxicity, and determine in-vivo anti-inflammatory.

The beneficial effect of Indonesian propolis wax from sp. as a therapy in limited vaginal candidiasis patients.

Vaginal candidiasis characterized by abnormal vaginal discharge and itching usually treated by azole's drug or nystatin; however, some results of treatment are unsatisfied and become recurrent. Propolis containing polyphenols and flavonoids is known to have anti-inflammatory and antimicrobial activity. This study investigated the effect of Indonesian propolis wax from sp.

Anti-inflammatory activity of species from Indonesia.

Anti-inflammatory drugs inhibit inflammation, particularly those classified as nonsteroidal anti-inflammatory drugs (NSAIDs). Several studies have reported that propolis has both anti-ulcerogenic and anti-inflammatory effects. In this study, we investigated the bioactive compound and anti-inflammatory properties of both smooth and rough propolis from .

Maternal exercise before and during gestation modifies liver and muscle mitochondria in rat offspring.

It is now well established that the intrauterine environment is of major importance for offspring health during later life. Endurance training during pregnancy is associated with positive metabolic adjustments and beneficial effects on the balance between pro-oxidants and antioxidants (redox state) in the offspring. Our hypothesis was that these changes could rely on mitochondrial adaptations in the offspring due to modifications of the fetal environment induced by maternal endurance training.

Maternal exercise modifies body composition and energy substrates handling in male offspring fed a high-fat/high-sucrose diet.

Key Points: Maternal training during gestation enhances offspring body composition and energy substrates handling in early adulthood. Offspring nutrition also plays a role as some beneficial effects of maternal training during gestation disappear after consumption of a high-fat diet.

Abstract: Maternal exercise during gestation has been reported to modify offspring metabolism and health.

Short-term and long-term effects of submaximal maternal exercise on offspring glucose homeostasis and pancreatic function.

Only a few studies have explored the effects of maternal exercise during gestation on adult offspring metabolism. We set out to test whether maternal controlled submaximal exercise maintained troughout all gestational periods induces persistant metabolic changes in the offspring. We used a model of 15-wk-old nulliparous female Wistar rats that exercised (trained group) before and during gestation at a submaximal intensity or remained sedentary (control group).