Role of Na+/H+ exchanger isoform-1 in human inflammatory bowel disease.

Background: Na+/H+ exchanger (NHE) is responsible for a net uptake of sodium chloride and water from the gastrointestinal tract and maintains electrolyte and water homeostasis. However, its status in human inflammatory bowel disease such as ulcerative colitis (UC) and Crohn's disease (CD) remains poorly understood.

Objectives: To investigate the role of NHE-1 isoform in human CD and UC.