Anti-inflammatory, analgesic activity, and toxicity of Pituranthos scoparius stem extract: An ethnopharmacological study in rat and mouse models.

Ethnopharmacological Relevance: Pituranthos scoparius is a medicinal plant that is used in traditional medicine in Algeria and other North African nations to treat several diseases such as asthma, rheumatism, measles, dermatoses, jaundice, and digestive disorders.

Aim Of The Study: The present investigation was designed to investigate an ethnobotanical survey about Pituranthos scoparius in Setif region, Algeria, and assess the acute toxicity, in vivo anti-inflammatory potential and analgesic effect of Pituranthos scoparius hydromethanolic stem extract (PSSE) in rats and mice models.

Materials And Methods: Acute toxicity of PSSE was carried out based on OECD guidelines 425.

Polymorphisms of 5,10-methylenetetrahydrofolate reductase and cystathionine beta-synthase genes as a risk factor for neural tube defects in Sétif, Algeria.

Background: Neural tube defects (NTD) are severe congenital malformations due to a failure in neural tube formation at the beginning of pregnancy. The etiology of NTD is multifactorial, with environmental and genetic determinants. We suggest a study of gene-gene interactions regarding the possible association of NTD with specific mutations of 5,10-methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS) genes.

The prevalence of methylenetetrahydrofolate reductase 677 C-T, factor V 1691 G-A, and prothrombin 20210 G-A mutations in healthy populations in Setif, Algeria.

The polymorphic mutation 677 C-T in the methylenetetrahydrofolate reductase (MTHFR) gene presents a heterogeneous worldwide distribution and is associated with different disorders such as cardiovascular disease. Its frequency shows great ethnic and geographic variations. The aim of this work is to determine the frequency of MTHFR 677 C-T and coexistence of MTHFR 677 C-T with 2 other common, hereditary thrombophilia causes-namely, factor V 1691 G-A and prothrombin (PT) 20210 G-A mutation-in the Sétif region of Algeria.