Publications by authors named "Farid Hamedi-Sangsari"
Article Synopsis
- The addition of 4-methylthio-2-oxobutanoate (MTOB) helps methionine-dependent cancer cells grow without methionine and transition state inhibitors can selectively target these cancer cells for inhibition.
- The transition state analogue L-methionine ethyl ester pyridoxal (MEEP) and the amine donor analogue D-aspartate beta hydroxamate (D-AH) effectively inhibit the MTOB transaminase enzyme in cancer cells, promoting apoptosis without affecting normal cells.
- MEEP shows 20 times greater efficacy than D-AH in inducing cancer cell death, highlighting MTOB transaminase as a promising target for developing selective anticancer therapies.
