The healing effect of nano emulsified Plantago major L extract on oral wounds in a wistar rat model.

Introduction: Oral lesions are a common clinical symptom arising from various etiologies and disrupt the patient's quality of life. However, no definite treatment is not yet possible, due to the constantly changing environment of the mouth. In recent years, herbal treatments have gained popularity among patients and physicians due to their availability, safety, affordability, and antimicrobial properties.

Synthesis and characterization of nano-biopolymer carriers loaded with clove ( L.) extract as an anticancer agent: an study.

The objective of this work was to design a new drug nanoparticle (NP) composed of chitosan/β-cyclodextrin/sodium tripolyphosphate/alginate (CS/βCD/TPP/AL) loaded with a clove extract (CE) for potential anticancer effects. The extract was prepared by two extraction methods: hydroalcoholic maceration (MAC) with 80% MeOH and supercritical fluid (SCF). The MACCE and SCFCE CE NPs had particle sizes of 71 nm and 20 nm, respectively with irregular spherical shapes.

Medicinal plants used in multiple sclerosis patients, prevalence and associated factors: a descriptive cross-sectional study.

Introduction: Multiple sclerosis (MS) is a chronic and debilitating disease that not only leads to disability and associated condition but also impacts one's ability to maintain a professional life. People's acceptance and utilization of medicinal plants (MPs) play an important role in managing their treatment process. As a result, this study aims to investigate the use of medicinal herbs among patients with MS.

Antioxidant and cytotoxicity activity of a nanoemulsion from Satureja kermanica (Lamiaceae).

Objective: Satureja kermanica is a native species with a relatively wide distribution in Iran, which has been studied less. Due to the low stability of the plants, in this study, the methanolic extract of S. kermanica (MSK) along with a nanoemulsion (NEK) preparation was evaluated in terms of antioxidant and cytotoxic activity.

Mannas, unique products of a dynamic insect-plant interaction: Biodiversity, conservation and ethnopharmacological considerations.

Biodiversity keeping increases the flexibility, interaction and adaptation of different ecosystems with the environment which benefits all organisms, including humans. This diversity can be maintained through different paths including co-evolution between insects and plants. One of these unique interactions leads to the production of "Mannas" in Iran, which have biological and ethno-medicinal importance.

Antimicrobial efficacy of different herbal extracts against root canal pathogens - An study.

Background: The antimicrobial activity exhibited by the plant extracts against various pathogens has previously been demonstrated to a limited extent. However, the antibacterial effects of most of them have not yet been clarified in endodontics.

Aim: This study aimed to determine the antimicrobial activity of some medicinal plants' methanolic extracts against some root canal microorganisms.

One-Step Preparation of Luteolin Nanoemulsion and Evaluation of its Anti-inflammatory Effect in Animal Models.

Background: Nanoemulsions are promising drug delivery systems for topical application owing to the high transdermal penetration.

Objective: Due to the side effects of existing anti-inflammatory drugs, much attention has been paid to natural products such as flavonoids. The aim of this work was to formulate luteolin nanoemulsion (LNE) and to evaluate its anti-inflammatory effect.

The potential effect of silver nanoparticles synthesized with green seeds on proliferation, cytotoxicity activity, and cytokines expression level.

The goal of this study was to analyze the antileishmanial and antibacterial activity of green seed biosynthesize silver nanoparticles ( AgNPs), as well as cytotoxicity and cytokine gene expression. UV-vis spectroscopy, FTIR, and FESEM methods used to examine the AgNPs. MTT test was used to assess the antileishmanial and cytotoxicity effects.

Ameliorating Effect of Standardized Extract From Textured Soy Protein ( L.) on Memory Deficit and Learning Insufficiency in Scopolamine-induced Amnesia.

Introduction: Textured soy protein (TSP) and nuts are two processed forms of soybean ( L.) that are widely consumed for nutritional purposes in Iran. Recently, we have reported the antioxidant and anticholinesterase effects of raw soybean (RS) attributed to isoflavones, such as genistein.

The Therapeutic Effects of on Skin Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

The aim of this systematic review was to identify randomized controlled trials that looked at the effects of in any form on different skin diseases. Up to March 2022, the online databases of Scopus, Web of Science, PubMed, Embase, Google Scholar, and Cochrane trials were searched. This study included 14 records of people who had experienced different types of skin disease including atopic dermatitis, vulgaris, arsenical keratosis, psoriasis, vitiligo, acute cutaneous leishmaniasis, warts, eczema, and acne.

Antileishmanial Effects of Bunium Persicum Crude Extract, Essential Oil, and Cuminaldehyde on Leishmania Major: In Silico and In Vitro Properties.

Purpose: Cuminaldehyde (CA), an oxidized aldehyde monoterpene, is a major essential oil component in cumin seeds, which has shown different promising medical effects. In this study, we comprehensively evaluated the antileishmanial potential of Bunium persicum (Boiss) B. Fedtsch (Apiaceae) and one of its main essential oil constituents, CA, focus on the mechanisms of action.

Rosemary as an adjunctive treatment in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial.

Background: Rosemary has shown antidepressant and anxiolytic properties. Thus, the present study aimed at assessing the therapeutic effects of orally administered rosemary capsules in patients with major depressive disorder.

Materials And Methods: Rosmarinic acid content of rosemary was determined using high performance liquid chromatography method.

Characteristics and in vitro anti skin aging activity and UV radiation protection of morin loaded in niosomes.

Background: One of the dermatologic problems in elderly people is skin aging, which is a natural and complex biological process. Morin is a flavonoid with high radical scavenging activity as well as antityrosinase effects but its low water solubility has restricted its application.

Aims: This research aimed to develop, characterize, and optimize morin niosomes composed of non-ionic surfactants, and evaluate the in vitro UV protection and antiaging effectiveness.

Lavender improves fatigue symptoms in multiple sclerosis patients: A double-blind, randomized controlled trial.

Background: Fatigue is one of the most common complications of Multiple Sclerosis (MS) patients. Several pharmacological and non-pharmacological interventions have been recommended to control this complication. Lavender is one of the plants considered by Persian Medicine (PM) and recommended by scholars of past centuries in the treatment of neurological diseases.

Evidence for Rosa damascena efficacy in mental disorders in preclinical animal studies and clinical trials: A systematic review.

The aim of this systematic review was to identify animal preclinical studies and randomized controlled trials that looked at the effects of R. damascena in any form on different mental diseases. Up to September 2021, the online databases of PubMed, Scopus, Embase, Web of Science, and Cochrane trials, as well as SID and MagIran, were searched.

Inhibitory Effect of Standardized Extract and Fractions of L. on Nystatin Susceptible and Clinically Nystatin Resistant Candida .

Introduction: Candidiasis infection is caused by different species of Candida, which are characterized by host immunologic weakness. Black cumin seeds (Nigella sativa) have shown an inhibitory effect against Candida albicans. In this work, the inhibitory effect of standardized extract and different fractions of Nigella sativa seeds has been evaluated on both nystatin-susceptible and resistant strain of C.

Diosgenin: Mechanistic Insights on its Anti-inflammatory Effects.

Diosgenin (DG), a well-known steroid saponin, has shown anti-inflammatory effects. This review was aimed to discuss all published literature concerning the anti-inflammatory effects of diosgenin. Based on the modulatory impact of DG on the NF-κB pathway, its supplementation is associated with downregulation of the NF-κB pathway and TGF-β, resulting in inhibition of inflammation.

Inhibitory effects of different fractions separated from standardized extract of against nystatin-susceptible and nystatin-resistant isolated from HIV positive patients.

Background: and Purpose: Myrtle (.) is a medicinal herb that plays an essential role in treating fungal infections. The present study investigated the antifungal properties of different fractions of the leaf extract against (susceptible and resistant to nystatin).

Anti-leishmanial activity of ( family) leaves hydroalcoholic extract and its possible cellular mechanisms.

Natural products are the main source of potent antioxidants and anti-leishmanial agents. This study was aimed to evaluate ( family) extract inhibitory effect against by accessing apoptotic markers and arginase activity. The were extracted and phytochemical analysis conducted.

Novel Synergistic Activity of Gall Extract with Ceftazidime Against Standard and Multiple Drug Resistant and Isolates.

Background: Multidrug resistance pathogens are important heath challenges. In this study, the antibacterial activity of 20 plant extracts was tested against standard as well as 20 multidrug-resistant () strains of and . The most active plant extract () was selected for the synergistic activity assay.

Silicon and nitric oxide synergistically modulate the production of essential oil and rosmarinic acid in Salvia officinalis under Cu stress.

The individual impact of silicon (Si) and nitric oxide (NO) on secondary metabolism in several plant species has been reported, but their combined effect has never been evaluated yet. Therefore, in this study, single and combined impacts of NO and Si on the biosynthesis of rosmarinic acid (RA) and essential oil (EO) content in leaves of Salvia officinalis were investigated under both non-stress and Cu stress conditions. The results indicated that high Cu concentration decreased biomass and the content of polyphenols, but elevated electrolyte leakage, while lower Cu concentrations, especially 200 μM Cu, increased the content of polyphenols, EO, and antioxidant capacity in leaves of S.

The effects of L. root extract on the opiate withdrawal syndrome and psychological factors: a randomized double-blind clinical trial.

Objectives: In this clinical trial, the effect of aqueous extract of L. was investigated on opiate withdrawal syndrome, depression, anxiety, stress, and sleep quality in opioid addicts which were under methadone maintenance therapy.

Methods: For this purpose, 52 opiate addicts were randomly selected of whom 28 received 500 mg capsules of extract (treatment) and the rest received 500 mg of starch capsules (placebo), twice daily for 4 weeks.

Leishmanicidal potentials of extract and its fractions on in a murine model: parasite burden, gene expression, and histopathological profile.

Leishmaniasis is a neglected tropical and subtropical disease caused by over 20 protozoan species. Treatment of this complex disease with traditional synthetic drugs is a major challenge worldwide. Natural constituents are unique candidates for future therapeutic development.

Ethnopharmacological Knowledge for Management of Oral Mucositis in Zahedan, Southeast Iran.

Objectives: Oral mucositis is among the complications of cancer therapy that affects quality of life and imposes remarkable financial costs for patients with cancer. This study aimed to explore, preserve, and scientifically investigate the ethnomedicinal knowledge of traditional healers for treatment of oral mucositis in Zahedan, Iran.

Materials And Methods: Field surveys were performed from September 2018 to October 2018 in Zahedan.