Determination of Regorafenib monohydrate (colorectal anticancer drug) solubility in supercritical CO: Experimental and thermodynamic modeling.

In this study, the solubilities of (), a widely used as a colorectal anticancer drug, in supercritical carbon dioxide (ScCO) were measured under various pressures and temperature conditions, for the first time. The minimum value of in mole fraction was determined to be 3.06×10, while the maximum value was found to be 6.

Studies on solubility measurement of codeine phosphate (pain reliever drug) in supercritical carbon dioxide and modeling.

In this study, the solubilities of codeine phosphate, a widely used pain reliever, in supercritical carbon dioxide (SC-CO) were measured under various pressures and temperature conditions. The lowest determined mole fraction of codeine phosphate in SC-CO was 1.297 × 10 at 308 K and 12 MPa, while the highest was 6.

Evaluation of a temperature-responsive magnetotocosome as a magnetic targeting drug delivery system for sorafenib tosylate anticancer drug.

In this investigation, a polymeric fusion of chitosan (CS) and thermosensitive poly (N-isopropyl acrylamide) - PNIPAAm - encapsulated a magnetotocosome, biocompatible nanocarrier. This encapsulation strategy demonstrated improved drug entrapment efficiency, achieving up to 98.8 %.

A machine learning approach for thermodynamic modeling of the statically measured solubility of nilotinib hydrochloride monohydrate (anti-cancer drug) in supercritical CO.

Nilotinib hydrochloride monohydrate (NHM) is an anti-cancer drug whose solubility was statically determined in supercritical carbon dioxide (SC-CO) for the first time at various temperatures (308-338 K) and pressures (120-270 bar). The mole fraction of the drug dissolved in SC-CO ranged from 0.1 × 10 to 0.

Solubility measurement and modeling of hydroxychloroquine sulfate (antimalarial medication) in supercritical carbon dioxide.

A supercritical fluid, such as supercritical carbon dioxide (scCO) is increasingly used for the micronization of pharmaceuticals in the recent past. The role of scCO as a green solvent in supercritical fluid (SCF) process is decided by the solubility information of the pharmaceutical compound in scCO. The commonly used SCF processes are the rapid expansion of supercritical solution (RESS) and supercritical antisolvent precipitation (SAS).

Experimental solubility and thermodynamic modeling of empagliflozin in supercritical carbon dioxide.

The solubility of empagliflozin in supercritical carbon dioxide was measured at temperatures (308 to 338 K) and pressures (12 to 27 MPa), for the first time. The measured solubility in terms of mole faction ranged from 5.14 × 10 to 25.

Solubility measurement and thermodynamic modeling of pantoprazole sodium sesquihydrate in supercritical carbon dioxide.

Knowing the solubility data of pharmaceutical compounds in supercritical carbon dioxide (ScCO) is essential for nanoparticles formation by using supercritical technology. In this work, solubility of solid pantoprazole sodium sesquihydrate in ScCO is determined and reported at 308, 318, 328 and 338 K and at pressures between 12 and 27 MPa. The solubilities are ranged between 0.

Investigation of Temperature-Responsive Tocosomal Nanocarriers as the Efficient and Robust Drug Delivery System for Sunitinib Malate Anti-Cancer Drug: Effects of MW and Chain Length of PNIPAAm on LCST and Dissolution Rate.

In this study, for the first time, the coated tocosome by blend of chitosan, CS, and poly(N-isopropylacrylamide), PNIPAAm, was developed as the efficient and robust drug delivery system with improved drug encapsulation efficiency, extended stability, proper particle size and industrial upscaling for Sunitinib malate anti-cancer drug. Tocosome was synthesized by using Mozafari method as a scalable and robust method and without the need for organic solvents. The effects of tocosome composition and drug concentration on the stability, particle size of tocosome, zeta potential, encapsulation efficacy and loading of drug into it were investigated by Taguchi method, and optimum composition was selected for combining with the polymeric blend.

Measurement and modeling of clemastine fumarate (antihistamine drug) solubility in supercritical carbon dioxide.

The solubilities of clemastine fumarate in supercritical carbon dioxide (ScCO) were measured for the first time at temperature (308 to 338 K) and pressure (12 to 27 MPa). The measured solubilities were reported in terms of mole faction (mol/mol total) and it had a range from 1.61 × 10 to 9.

Solubility of Ketoconazole (antifungal drug) in SC-CO for binary and ternary systems: measurements and empirical correlations.

One of the main steps in choosing the drug nanoparticle production processes by supercritical carbon dioxide (SC-CO) is determining the solubility of the solid solute. For this purpose, the solubility of Ketoconazole (KTZ) in the SC-CO, binary system, as well as in the SC-CO-menthol (cosolvent), ternary system, was measured at 308-338 K and 12-30 MPa using the static analysis method. The KTZ solubility in the SC-CO ranged between 0.

Diffusional interaction behavior of NSAIDs in lipid bilayer membrane using molecular dynamics (MD) simulation: Aspirin and Ibuprofen.

In this research, for the first time, molecular dynamics (MD) method was used to simulate aspirin and ibuprofen at various concentrations and in neutral and charged states. Effects of the concentration (dosage), charge state, and existence of an integral protein in the membrane on the diffusion rate of drug molecules into lipid bilayer membrane were investigated on 11 systems, for which the parameters indicating diffusion rate and those affecting the rate were evaluated. Considering the diffusion rate, a suitable score was assigned to each system, based on which, analysis of variance (ANOVA) was performed.

Molecular dynamics simulation study of chitosan and gemcitabine as a drug delivery system.

By using molecular dynamics (MD) simulation, biodegradable biopolymer chitosan as a carrier for the drug gemcitabine was investigated and the effect of three initial drug concentrations (10, 40, and 80%) on its loading efficiency was studied. Then water was added to the systems of drug and biopolymer and the effects of water on the interactions of drug and chitosan and on the drug loading efficiency were examined. From the results it was found that the maximum loading of the drug occurred at 40% of the drug concentration.