The molecular characterization of colistin-resistant isolates of from patients at intensive care units.

Background And Objectives: The objective of this study was to determine molecular characterization and genetic diversity of colistin-resistant clinical isolates in Intensive Care Unit hospitalized patients.

Materials And Methods: A total of 127 clinical isolates were evaluated for antimicrobial susceptibility. PCR reaction and sequencing were performed for the detection of mutations in and genes.

Micronutrient therapy and effective immune response: a promising approach for management of COVID-19.

The escalating prevalence of coronavirus disease 2019 (COVID-19) worldwide, with an increased rate of morbidity and mortality, highlights an urgent need to develop more effective therapeutic interventions. Despite the authorized treatment against COVID-19 by the European Union (EU), the safety and effectiveness of this therapeutic strategy for a wide variety of patients have remained a significant challenge. In this respect, micronutrients such as vitamins and minerals, as essential factors, can be considered for improving the function of the immune system and accelerating the treatment procedure.

Crosstalk between miRNAs and signaling pathways involved in pancreatic cancer and pancreatic ductal adenocarcinoma.

Pancreatic cancer (PC) is the seventh leading cause of cancer-related deaths worldwide with 5-year survival rates below 8%. Most patients with PC and pancreatic ductal adenocarcinoma (PDAC) die after relapse and cancer progression as well as resistance to treatment. Pancreatic tumors contain a high desmoplastic stroma that forms a rigid mass and has a potential role in tumor growth and metastasis.

Plasmonic all-optical switching based on metamaterial/metal waveguides with local nonlinearity.

We present a plasmonic all-optical switch based on Mach-Zehnder interferometer (MZI) with local nonlinearity. The design of the miniaturized all-optical switch is possible by employing surface-plasmon polaritons (SPPs) that confine the energy of electromagnetic (EM) waves at sub-wavelength scale. The coupling between sub-wavelength plasmonic waveguides in MZI and a control beam generates 'ON' and 'OFF' states at the switch and switching between 'ON' and 'OFF' states happens when the control beam is turned on or off.