Publications by authors named "Farhat Parween"
Article Synopsis
- - The study focuses on Th17 cells, which are known for their role in autoimmune diseases; however, the differentiation pathways and memory structure of these cells in humans are still not fully understood.
- - Researchers utilized surface markers like CCR6 to examine human type 17 memory cells, revealing a continuum of cell types influenced by RORγt levels that reflects early activation preferences.
- - While the properties of CCR6+ cells remain stable under non-inflammatory conditions, varying activation environments can further alter their functions, showcasing both adaptability and a complex memory in type 17 cells.
Article Synopsis
- Pro-inflammatory T cells, specifically Th17 cells, express multiple chemokine receptors, but their individual functions were previously unclear, particularly focusing on CCR6 and CCR2.
- Our research identified a specific subgroup of CD4CCR6 T cells that not only have a pathogenic Th17 signature but can also produce inflammatory cytokines without TCR activation and are highly efficient in transendothelial migration (TEM).
- We found that while CCR6 can help these cells arrest on activated endothelial cells, it does not facilitate TEM, and CCR2 is critical for TEM despite not mediating arrest; this suggests that the functions of chemokine receptors in lymphocyte migration are complex and context-dependent.
Article Synopsis
- Th17 cells have mostly been studied in mice for their role in autoimmune diseases, but their differentiation and memory structures in humans remain poorly understood.
- Researchers used varying levels of surface CCR6 to show that human type 17 memory cells exist in a continuum that reflects their developmental pathways, influenced by the protein RORγt.
- The phenotypes and epigenomes of these CCR6 cells are stable, but different activation conditions can lead to new functionalities, demonstrating the unique adaptability of type 17 cells.
Prohibitin is a highly conserved ubiquitously expressed protein involved in several key cellular functions. Targeting of this protein in the membrane by the virulence polysaccharide, Vi, of human typhoid-causing pathogen, Salmonella enterica serovar Typhi (S. Typhi), results in suppression of IL-2 secretion from T cells activated through the T-cell receptor (TCR).
View Article and Find Full Text PDFHuman MAIT cells show little expression of the selectin CD62L and the chemokine receptor CCR7, which are important for entering lymph nodes, and high expression of selectin ligands and chemokine receptors that mediate trafficking into inflamed tissue. Extravasation of leukocytes into tissue requires sequential steps including rolling, firm arrest, crawling, and transendothelial migration, and can be modeled using endothelial cell monolayers in flow chambers that approximate the sheer stress found in post-capillary venules. Using MAIT cells purified from elutriated lymphocytes by fluorescence-activated cell sorting, we have used flow chambers to demonstrate roles for individual chemokine receptors in specific steps required for extravasation.
View Article and Find Full Text PDFVi capsular polysaccharide (Vi) is a major virulence factor of human typhoid-causing pathogen serovar Typhi (. Typhi). It distinguishes .
View Article and Find Full Text PDFOvarian cancer (OC) is one of the most lethal cancers among all gynecological malignancies. An effective and non-invasive screening approach is needed urgently to reduce high mortality rate. The purpose of this study was to identify the salivary protein signatures (SPS) for non-invasive detection of ovarian cancer.
View Article and Find Full Text PDFT cells are critical to immunity against pathogenic Salmonella including Salmonella Typhi which causes systemic infection, typhoid, in humans. The strategies that this pathogen employs to keep T-cell mediated immune responses in check during establishment of systemic infection are not completely understood. Here, we show that the virulence polysaccharide Vi, which distinguishes S.
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