Fungicide resistance in Fusarium species: exploring environmental impacts and sustainable management strategies.

The agricultural productivity and world-wide food security is affected by different phytopathogens, in which Fusarium is more destructive affecting more than 150 crops, now got resistance against many fungicides that possess harmful effects on environment such as soil health, air pollution, and human health. Fusarium fungicide resistance is an increasing concern in agricultural and environmental contexts, requiring a thorough understanding of its causes, implications, and management approaches. The mechanisms of fungicide resistance in Fusarium spp.

Efficacy of Intravenous Versus Oral Administration of Levocarnitine in Maintenance Hemodialysis Patients: A Randomized Controlled Trial Investigating Therapeutic Approaches to Renal Anemia.

Background And Aim: Carnitine deficiency contributes to various comorbidities in maintenance hemodialysis (MHD) patients. This study aims to assess the impact of levocarnitine supplementation on hematological and serum iron profile parameters, comparing the efficacy of oral versus intravenous (IV) administration in these patients.

Materials And Methods: This was a multicenter, randomized controlled trial was conducted on patients undergoing MHD at the hemodialysis unit of our study center in Karachi, Pakistan.

Artemisinin Suppressed Melanoma Recurrence and Metastasis after Radical Surgery through the KIT/PI3K/AKT Pathway.

Cancer radical surgery is the primary treatment for melanoma, but almost all malignant melanoma patients get recurrence and metastasis after surgery and are eventually dead. This clinical dilemma appeals to better drugs for post-surgery therapy. Artemisinin is a safe and effective antimalarial drug used in the clinic for decades.

Risk assessment tool for compatibility of concurrent administration of intravenous medications with parenteral nutrition admixture.

Compatibility of parenteral nutrition admixture (PNA) and intravenous medications (IVMs) is a major consideration for clinicians and clinical pharmacists, especially when concurrent administration of PNA with IVMs is unavoidable. This is relatively common in children and neonates, where limited vascular access can be challenging. The purpose of this paper is to create a risk assessment tool that will assist clinical judgment in evaluating the potential incompatibility risk between PNA media and the IVMs when they are administered together through the same intravenous line.

Optimizing tilt angle of PV modules for different locations using isotropic and anisotropic models to maximize power output.

The optimal integration of Photovoltaic (PV) systems into an electric grid is dependent upon the total output power of the PV system. To optimize the output power of a PV system, the modules must be positioned at an optimal tilt angle (OTA) to maximize the absorption of solar radiations. This research focused on a mathematical model to optimize incident solar radiation.

Theoretical biological activities and docking studies of new derivatives of acyclovir for the treatment of coronavirus disease 2019.

Acyclovir is an established antiviral agent. The global emergence of the coronavirus disease 2019 (COVID-19) pandemic brought forth the necessity to investigate potential therapeutic attributes of existing drugs, including acyclovir, to combat this novel virus. The primary focus of this research was to assess the theoretical bioactivities of acyclovir derivatives and to evaluate their molecular docking capacities, thereby determining their prospective application in treating COVID-19.

A near-complete genome reveals the population evolution of the cotton-melon aphid Aphis gossypii.

The cotton-melon aphid Aphis gossypii Glover is a severe pest worldwide. Interhaplotype genomic variation can be used as a starting point to analyze the adaptability of Ap. gossypii.

Phytoremediation potential of potted plant species against vehicular emissions.

Urbanization and industrialization are exponentially deteriorating air quality, ecosystems, and human health. Phytoremediation is cost cost-effective, sustainable, and nature-based solution against air pollution. This study is designed to evaluate four species, , a, , and for their phytoremediation potential.

Characterization, Codon Usage Pattern and Phylogenetic Implications of the Waterlily Aphid (Hemiptera: Aphididae) Mitochondrial Genome.

The water lily aphid, , is the only known aphid that can live in both terrestrial and aquatic conditions. In this study, the complete mitochondrial genome of was generated using Illumina sequencing technology. The typical circular DNA mitochondrial genome of is 15,772 bp in length, with a high A+T content (84.

Multiphasic Acute Disseminated Encephalomyelitis with a Temporal Gap of 26 Years: A Case Report with Novel Presentation.

Introduction: Acute disseminated encephalomyelitis (ADEM) is an acute autoimmune demyelinating disease of the central nervous system that typically follows an acute viral infection or post-vaccination. It is more common in children than in adults and is characterized by widespread demyelination of the white matter of the brain and spinal cord. ADEM typically presents as a monophasic illness.

The Potential Role of Polyphenol Supplementation in Preventing and Managing Depression: A Review of Current Research.

Depression is a common mental illness that affects 5% of the adult population globally. The most common symptoms of depression are low mood, lack of pleasure from different activities, poor concentration, and reduced energy levels for an extended period, and it affects the emotions, behaviors, and overall well-being of an individual. The complex pathophysiology of depression presents challenges for current therapeutic options involving a biopsychosocial treatment plan.

Robust regenerable metal-selenide-chitosan photocatalyst for the effective removal of Bromothymol Blue (BB) from wastewater.

Water scarcity has been a crucial debate in recent years regarding the critical scenario of water pollution. The water body is continuously contaminated by organic effluents of textile industries, including pigmented dye pollutants. To tackle water bodies contamination, there is a need to develop an eco-friendly and efficient method for removing toxic dyes.

Haploinsufficiency of in Striatal Indirect Pathway Neurons Alters Motor and Goal-Directed Behaviors in Mice.

is a high-confidence autism spectrum disorder (ASD) risk gene, and mutations in lead to a neurodevelopmental disorder (NDD) that presents with epilepsy, ASD, motor developmental delay, and intellectual disability. codes for Ras/Rap GTP-ase activating protein SynGAP (SynGAP). SynGAP is located in the postsynaptic density of glutamatergic synapses and regulates glutamate receptor trafficking in an activity-dependent manner.

Clinical Trial Findings and Drug Development Challenges for Curcumin in Infectious Disease Prevention and Treatment.

Since ancient times, turmeric, scientifically known as , has been renowned for its therapeutic properties. Recently, extensive documentation has highlighted the prevalence of microbial diseases without effective treatments, the increased expense of certain antimicrobial medications, and the growing occurrence of antimicrobial drug resistance. Experts predict that drug resistance will emerge as a significant global cause of death by the middle of this century, thereby necessitating intervention.

Effect of Co-Diet Supplementation on Biodegradation of Polyethylene by L. (Lepidoptera: Pyralidae).

Pollution coming from plastic polymers, particularly polyethylene (PE), poses a serious threat to both humans and animals. The biodegradation of plastics facilitated by insects is a crucial and eco-friendly approach that can be employed to combat this global concern. Recently, the larvae of the greater wax moth (L.

Letter to editor: A randomized controlled trial of social media promotion in neurosurgical publishing.

This letter recognizes the authors' commendable work in examining the role of social media in promoting neurosurgical research. It also underscores the necessity for more robust methodologies in future studies to clearly assess the impact of social media promotion and to ensure that findings are generalizable, addressing the limitations of the current study.

Harnessing AI and analytics to enhance cybersecurity and privacy for collective intelligence systems.

Collective intelligence systems like Chat Generative Pre-Trained Transformer (ChatGPT) have emerged. They have brought both promise and peril to cybersecurity and privacy protection. This study introduces novel approaches to harness the power of artificial intelligence (AI) and big data analytics to enhance security and privacy in this new era.