Publications by authors named "Farhan Alam"
Parkinson's disease (PD) is associated with a reduction in 26/20S proteasome and mitochondrial function and depletion of dopamine. Activation of mitochondrial function with the NAD precursor nicotinamide riboside (NR) is a potential therapeutic for PD. However, despite recently started clinical trials, analysis of NR in mammalian animal PD models is lacking and data in simpler PD models is limited.
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- MICHA (Minimal Information for Chemosensitivity Assays) is a new platform that enhances the consistency and transparency of chemosensitivity assays by providing detailed annotations for compounds, samples, reagents, and data processing methods.* -
- The platform allows users to easily access and extract publicly available information, such as chemical structures and disease indications, while also offering curated protocols and literature references.* -
- By adhering to the FAIR principles, MICHA promotes better integration of data from different studies, facilitating open access to drug sensitivity information and supporting community-driven research efforts.*
Article Synopsis
- Chemosensitivity assays help scientists find out which drugs work best against diseases, but sometimes they get confusing results due to different methods used in experiments.
- MICHA is a new tool that helps make sense of this by collecting important information automatically about drugs, samples, and testing methods from the internet.
- By using MICHA, researchers can create easy-to-read reports and share their findings, making it easier for everyone to understand which drugs are effective, especially for cancer and COVID-19 studies.
Purpose: The aim of the study was to determine the efficacy of whole body vibration (WBV) therapy on pain, neuropathy disability score, balance, proprioception and quality of life (QOL) in patients with painful diabetic peripheral neuropathy (PDPN).
Methods: Twenty-six (16 males and 10 females) patients with PDPN were selected on the basis of inclusion and exclusion criteria. Subjects were randomly allocated to an experimental group ( = 13, age = 60.
: Flexibility and strength are compromised in pronated feet, which could in turn lead to alteration of the dynamic balance and muscle activity in the lower extremities. This study aimed to analyze the effects of selective tibialis posterior strengthening and iliopsoas stretching on navicular drop, dynamic balance, and lower limb muscle activity in young adults with pronated feet. : Twenty-eight participants with pronated feet were randomly assigned to either the stretching and strengthening group ( = 14) or the conventional exercise group ( = 14).
View Article and Find Full Text PDFIonic Ca2+ functions as a second messenger to control several intracellular processes. It also influences intercellular communication. The release of Ca2+ from intracellular stores through the inositol 1,4,5-trisphosphate receptor (InsP3R) occurs in both excitable and nonexcitable cells.
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