Improvement of ovarian function in a premature ovarian failure mouse model using Vitex agnus-castus extract.

Objective: Premature ovarian failure (POF) leads to infertility. Numerous researchers have endeavored to enhance ovarian function through antioxidant interventions. Extract from Vitex agnus-castus (VAC) has demonstrated a protective effect.

Cochlear reimplantation rate, causes, and outcomes: a multicenter study.

Objective: The current study aimed to evaluate cochlear reimplantation rate, causes, and audiological outcomes in a large group of patients in a multicenter study.

Methods: This retrospective study was conducted on patients with cochlear reimplantation surgeries between 2000 and 2022 in five academic referral centers. The rate and reasons for cochlear reimplantation surgeries were evaluated.

Enhancing the efficacy of low doses of N-acetyl-L-cysteine in mitigating CCl-induced hepatotoxicity in animal model using physical cold plasma.

Liver diseases have become widespread especially due to various factors of modern life. Although the effect of N-acetyl-L-cysteine (NAC) is investigated in the recovery of liver damage, gas plasma therapy can be identified as a promising candidate. Our study aimed to enhance the effectiveness of ineffective doses of NAC in stopping CCl-induced hepatotoxicity in rats by physical cold plasma.

Management of head and neck cancer of unknown primary: A phase IV study by DAHANCA.

Background: Diagnostic and therapeutic management of patients with head and neck squamous cell carcinoma of unknown primary (HNSCCUP) remains a challenge. The aim of the present phase IV study was to assess adherence to the current Danish guidelines and evaluate the treatment outcome in HNSCCUP patients.

Materials And Methods: Prospectively collected data in the DAHANCA database from patients treated between 2014 and 2020 was evaluated.

Effects of enriched environment on barrel cortex and hippocampus function following somatosensory damage in rat.

Objectives: This study investigated the effects of environmental enrichment (EE) on the behavior and histological alterations of rats with barrel cortex damage.

Methods: Forty-eight adult male rats were divided into Control (Ctrl), Lesion, Lesion+EE.S (Lesion+Standard Enriched Environment, and Lesion+EE.

Advancing 3D dental scanning: The use of photogrammetry with light detection and ranging for edentulous arches.

Statement Of Problem: The advent of computer-aided design and computer-aided manufacturing (CAD-CAM) has necessitated the acquisition of digital scans. However, there are limitations and problems with acquiring accurate 3-dimensional (3D) casts from edentulous patients, especially in the presence of saliva.

Purpose: The purpose of this in vitro study was to develop a novel approach for obtaining 3D casts of edentulous arches by using 2-dimensional (2D) images as an alternative to traditional 3D scanners with and without light detection and ranging (LiDAR).

Capitonnage Versus Non-Capitonnage in Pediatric Pulmonary Hydatid Disease: A Systematic Review and Meta-Analysis.

Background And Aim: Pulmonary hydatid disease, caused by , presents significant clinical challenges, particularly in pediatric populations. Surgical intervention remains the gold standard for treatment, with various techniques employed, including capitonnage and non-capitonnage methods. This systematic review and meta-analysis evaluates the efficacy and safety of capitonnage compared to non-capitonnage techniques in children.

Molecular and behavioral effects of Acamprosate in male rats with sodium salicylate-induced tinnitus.

Background: Imbalance in inhibitory and excitatory neurotransmitters have been reported in tinnitus. Acamprosate modulates the excitatory and inhibitory neurotransmission in the nucleus accumbens (NAc). This study aims to assess the effect of Acamprosate on tinnitus, anxiety, depression, and molecular changes in nucleus accumbens (NAc), in Sodium-Salisylate (S-salicylate) model of tinnitus.

Carcinogenic and non-carcinogenic risks caused by rice contamination with heavy metals and their effect on the prevalence of cardiovascular disease (Using machine learning).

Introduction: The safety and health of food products are essential in the food industry, and the risk of contamination from various contaminants must be evaluated. Exposure to HMs from the environment (especially food) causes various adverse effects on the body and increases the risk of cardiovascular disease (CVD).

Material And Method: Volunteers in the study comprised both healthy individuals and those with CVD.

Short-term and long-term exposure to particles and their consequences in Poldokhtar City (Iran).

In Iran's biggest towns, deaths and hospitalizations from respiratory and cardiovascular diseases have a strong association with PM pollution concentrations. The WHO recommends assessing the health impacts using the Air Quality and Health Evaluation approach (Air Q 2.2.

Epidemiology and treatment outcome of nasopharyngeal carcinoma in a low-incidence population - a DAHANCA analysis in Denmark 2000-2018.

Introduction: Nasopharyngeal carcinoma (NPC) is a rare disease and most studies have therefore been conducted in endemic areas. The aim of this study was to describe epidemiology and treatment outcomes of NPC in a population-based, non-endemic setting.

Material And Methods: Patients with NPC diagnosed in Denmark from 2000 to 2018 were identified in the Danish Head and Neck Cancer Study Group (DAHANCA) database.

Co-delivery of temozolomide and quercetin with folic acid-conjugated exosomes in glioblastoma treatment.

The study aims to improve glioblastoma multiforme (GBM) treatment by combining temozolomide (TMZ) and quercetin (Qct), using folic acid (FA)-conjugated exosomes to overcome TMZ resistance and enhance blood-brain barrier (BBB) penetration. Exosomes were isolated and after characterizing and modifying their surfaces with FA, drug loading of TMZ and Qct into exosomes was done. assays, including cell viability tests, RT-PCR, Western-blotting and flow-cytometry, were performed using U87MG and U251MG GBM cell lines.

Sustained co-release of ciprofloxacin and dexamethasone in rabbit maxillary sinus using polyvinyl alcohol-based hydrogel microparticle.

Topical delivery to paranasal sinuses through sustained-release stents is one of the new horizons in treating chronic rhinosinusitis (CRS). This study aims to introduce and evaluate sustained co-release of encapsulated ciprofloxacin (CIP) and dexamethasone (DEX) in polyvinyl alcohol-based carriers within the maxillary sinus of rabbit animals. DEX and CIP were loaded in a tyramine-substituted polyvinyl alcohol microparticle (PVATyr MP).

The level, source, and health outcome of PM exposure in Southwest Iran.

Introduction: Dusty storms considerably increase airborne particles in dry and semi-dry locations, such as deserts with no plants and strong winds. Therefore, the environment and people are affected severely. Ahvaz, an important metropolis, is often polluted by neighboring nations.

The Interplay between Mitochondrial Metabolism and Nasal Mucociliary Function as a Surrogate Method to Diagnose Thyroid Dysfunction: Insights from a Population-Based Study.

. This study aims to explore alternative diagnostic methods to assess thyroid function in patients unable to undergo blood tests for thyroid-stimulating hormones (TSH) and thyroxine (T4), such as individuals with trypanophobia, severe medical conditions, or coagulopathy. Considering the impact of thyroid dysfunction on mitochondrial metabolism and the essential role of proper mitochondrial function in ciliary motility, we postulate that assessing nasal ciliary function could serve as a surrogate diagnostic approach for thyroid dysfunction.

Acute toxicities in proton therapy for head and neck cancer - A matched analysis of the DAHANCA 35 feasibility study.

Background And Purpose: As preparation for a national randomized study comparing proton radiotherapy to photon radiotherapy, DAHANCA 35, we performed a non-randomized pilot study to investigate patient selection, logistics, planning, and treatment delivery. With the present study, as a comprehensive safety analysis, we want to compare toxicity during and up to two months after therapy to a historically matched group of patients treated with photon radiotherapy.

Materials And Methods: 62 patients treated with protons were matched to 124 patients who received photon treatment outside a protocol.

A new approach to prevent radiation-induced xerostomia using intraglandular injection of mitochondria-boosting agents.

Radiotherapy in patients with head and neck cancer fairly leads to xerostomia, profoundly affecting their quality of life. With limited effective preventive and therapeutic methods, attention has turned to exploring alternatives. This article outlines how intraglandular injection of mitochondria-boosting agents can serve as a potential strategy to reduce salivary acinar damage.

Exposure to Mercury in the Air and Its Effect on Cardiovascular Diseases (CVD): A Systematic Review.

Background: We aimed to verify the exposure to mercury in the air and its effect on cardiovascular disorders.

Methods: The review was conducted using PubMed, Scopus, Web of Science, Embase, and national databases (such as SID) from 1995-2022.

Results: Mercury exposure can cause many disorders in humans, including neurodevelopmental disorders in fetuses and children, adverse cardiovascular outcomes, hypertension, and diabetes.

Fumaria vaillantii extract protects PC12 cells against neurotoxicity induced by 6-OHDA.

Background: Parkinson's disease is a neurological disorder caused by the loss of dopaminergic neurons in the midbrain. Various mechanisms are involved in the incidence of the disease including oxidative stress. Several herbs and natural products may interfere with the oxidative-stress pathway due to their antioxidant effects.

Evaluation of carcinogenic risk of heavy metals due to consumption of rice in Southwestern Iran.

Pollution by heavy metals is a serious global problem due to its toxicity, abiotic characteristics, abundant sources, and cumulative behavior. On the other hand, considering the importance of rice consumption as an important part of nutrition in Lordegan and Ahvaz cities, this study was conducted to evaluate the carcinogenic risk of heavy metals lead, cadmium, zinc, nickel and in local Champa rice cultivated in these two cities. 16 Champa rice samples were collected from the fields of Lordegan and Ahvaz cities.