Thermosensitive and mucoadhesive gels containing solid lipid nanoparticles loaded with fluconazole and niosomes loaded with clindamycin for the treatment of periodontal diseases: a laboratory experiment.

Background: Periodontal diseases may benefit more from topical treatments with nanoparticles rather than systemic treatments due to advantages such as higher stability and controlled release profile. This study investigated the preparation and characterization of thermosensitive gel formulations containing clindamycin-loaded niosomes and solid lipid nanoparticles (SLNs) loaded with fluconazole (FLZ), as well as their in vitro antibacterial and antifungal effects in the treatment of common microorganisms that cause periodontal diseases.

Methods: This study loaded niosomes and SLNs with clindamycin and FLZ, respectively, and assessed their loading efficiency, particle size, and zeta potential.

Efficacy and safety of topical rosuvastatin & melatonin vs. placebo in patients with mild to moderate plaque psoriasis: A preliminary randomized double-blinded clinical trial.

Background: Considering the pathogenesis of psoriasis and also the anti-oxidant, immunomodulatory, and anti-inflammatory properties of rosuvastatin and melatonin, the current clinical trial aimed to evaluate the efficacy of topical rosuvastatin and melatonin in patients with mild to moderate psoriasis.

Methods: The current randomized placebo-controlled clinical trial was conducted using a 3-arm parallel group included 77 adult patients (≥18 years old) with mild to moderate plaque psoriasis. Patients were randomized into a 1:1:1 ratio to one of three groups to receive one of the three interventions: melatonin cream, 5.

Nanotechnology-Based Drug Delivery Systems in the Transdermal Treatment of Melanoma.

The incidence rate of melanoma is dramatically increasing worldwide, raising it to the fifth most common cancer in men and the sixth in women currently. Resistance generally occurs to the agents used in chemotherapy; besides their high toxicity destroys the normal cells. This study reviewed a detailed summary of the structure, advantages, and disadvantages of nanotechnology-based drug delivery systems in the treatment of melanoma, as well as some nanocarrier applications in animal models or clinical studies.

The effect of repeated porcelain firings on the marginal fit of millable and conventional casting alloys.

The durability of dental restorations is highly determined by an accurate marginal fit, which is in turn affected by the high temperature of porcelain firing. Information is inadequate about the marginal adaptation of metal-ceramic restorations fabricated by soft metal milling technologies after repeated firings. This study aimed to compare the effect of repeated ceramic firings on the marginal fit of copings fabricated from cobalt-chromium through soft metal milling and a conventional nickel-chromium casting alloy.

Workplace violence against health care workers during the COVID-19 Pandemic: A systematic review and meta-analysis.

Introduction: During the COVID-19 pandemic, Health Care Workers (HCWs) have been at the frontline against the disease and have direct contact with patients and their companions, so they are exposed to all sorts of Workplace Violence (WPV). The aim of this study was to investigate the prevalence of WPV against HCWs during the COVID-19 pandemic.

Method: This study was conducted according to the PRISMA guideline, and its protocol was registered at the PROSPERO under the code of CRD42021285558.

Development and characterization of a copolymeric micelle containing soluble and insoluble model drugs.

Objectives: Micelles are nano-sized particles with a core-shell structure that are made by natural or synthetic polymers or copolymers. The aim of this study was to develop and characterize a copolymeric micelle using two polymers loaded with hydrophilic and lipophilic drugs.

Methods: Poly(ethylene glycol) and poly(ε-caprolactone) (PEG-PCL) were used to form a copolymeric micelle which was further loaded with either moxifloxacin or clarithromycin as hydrophilic and lipophilic drug samples, respectively.

Impact of licorice root on the burn healing process: A double-blinded randomized controlled clinical trial.

Ethnopharmacological Relevance: Due to the known side effects of many synthetic drugs, the use of herbal and natural substances in treating diseases such as burns has been considered. licorice is a herbal medicine whose stem and underground roots are used in traditional medicine in many countries, including Iran, for anti-inflammatory, stomach ulcer healing, and antimicrobial purposes.

Aim Of The Study: This study investigated the healing effect of hydroalcoholic extract of licorice root on the wound healing process caused by second-degree burns.

Influence of specimen geometry and notch on fatigue lifetime and fracture behavior of aluminum-based nanocomposite under stress-controlled fully-reversed bending loads.

Introduction: In the present article, the effect of the specimen geometry and the sample notch was studied on the high cycle fatigue lifetime and fracture behavior of the aluminum-based nanocomposite.

Methods: For such an objective, rotary fully-reversed bending fatigue tests were performed on smooth and notched specimens, with the frequency of 100 Hz. Then, simulated results using the MSC Fatigue software were calculated and compared to the fatigue lifetime in the experiments for validation.

The effects of provisional resin cements on the color and retentive strength of all-ceramic restorations cemented on customized zirconia abutments.

This study aimed to evaluate the effects of two types of provisional resin cements on the color and retentive strength of two different all-ceramic restorations cemented onto customized zirconia abutments. Forty-two crowns were made of monolithic zirconia and lithium disilicate ceramics (n = 21 per group) and cemented on customized zirconia abutments by using two provisional resin cements of TempBond Clear and Implantlink Semi, and TempBond serving as the control (n = 7 per cement subgroup). The specimens' color was measured before and after cementation and after thermocycling.

The preventive effect of the combination of atorvastatin and nortriptyline in migraine-type headache: a randomized, triple-blind, placebo-controlled trial.

Background And Purpose: Migraine ranked as the eighth cause of disability worldwide. Statins with anti-inflammatory and vasodilatory endothelial effects have been introduced as an option for the prevention of migraine-type headaches. The current study aimed to assess the efficacy and tolerability of atorvastatin for the prevention of migraine in adults.

Effects of Donepezil and Medroxyprogesterone Versus Placebo on Weaning in Adult Patients With Non-Pulmonary Etiologies Receiving Invasive Mechanical Ventilation: A triple-blind Randomized Clinical Trial.

Medroxyprogesterone and donepezil could be used as respiratory stimulants in ventilated patients. However, no randomized placebo-controlled trial is available to confirm this approach and compare these drugs. The aim of the current study was to evaluate the effects of donepezil or medroxyprogesterone compared to the placebo in improvement in respiratory status and weaning facilitation in critically ill adult patients receiving mechanical ventilation.

Effect of a Surface Sealant Agent on the Color Stability and Surface Roughness of Polymethyl Methacrylate and Nylon Denture Base Materials.

Purpose: To evaluate the effect of a surface sealant agent on the color stability and surface roughness (Ra) of two denture base materials: polymethyl methacrylate (PMMA) and nylon.

Materials And Methods: A total of 96 disk-shaped specimens (10 × 2 mm) were fabricated from heat-cured PMMA and nylon denture base materials (n = 48/material). Each of the color stability and Ra tests were performed on half of the samples in each material group (n = 24), and these subgroups were then subdivided according to the surface treatment applied: 12 specimens were conventionally polished, serving as the control group, and 12 specimens received a sealant on the surface in addition to the surface polishing.

Hybrid Scaffolds of Hyaluronic Acid and Collagen Loaded with Prednisolone: an Interesting System for Osteoarthritis.

Cartilage regeneration by using polymeric scaffolds is a new option for treatment of osteoarthritis. A good scaffold for tissue engineering should copy the characteristics of natural extracellular matrix. The purpose of this study was to make a dosage form with proper reliability and stability for cartilage repair.

Effects of dietary supplementation of waste date's vinegar on performance and improvement of digestive tract in broiler chicks.

Two hundred 1-day-old commercial broilers (Ross 308) were used to determine the effects of diets supplementation with waste date's vinegar (WDV) on the growth and performance of digestive tract over a 42-days growing period. Chicks were randomly allocated to one of five experimental diets supplementing as 0 (control), 1, 2, and 3% of WDV and 2% industrial vinegar (IV). Broilers and their feed consumptions were weighed at the trial beginning and days 10, 21, 35 and 42 of experimental period.

Meloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation.

Objective(s): Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. Meloxicam is one of NSAIDs with no topical form in the market.

Effects of cinnamon consumption on glycemic status, lipid profile and body composition in type 2 diabetic patients.

Objective: Type 2 diabetes is the most common metabolic disorder worldwide. Traditional herbs and spices can be used to control blood glucose concentrations. The objective of this study was to evaluate the effects of the daily intake of three grams cinnamon over eight weeks on glycemic status, lipid profiles and body composition in type 2 diabetic patients.