Rationale and Design of a Genetic Study on Cardiometabolic Risk Factors: Protocol for the Tehran Cardiometabolic Genetic Study (TCGS).

Background: Cardiometabolic risk factors comprise cardiovascular diseases and/or diabetes, and need to be evaluated in different fields.

Objective: The primary aim of the Tehran Cardiometabolic Genetic Study (TCGS) is to create a comprehensive genome-wide database of at least 16,000 Tehranians, who are participants of the ongoing Tehran Lipid and Glucose Study (TLGS) cohort.

Methods: TCGS was designed in collaboration with the Research Institute for Endocrine Sciences and the genetic company deCODE.

CVD-predictive performances of "a body shape index" versus simple anthropometric measures: Tehran lipid and glucose study.

Purpose: To examine whether a body shape index (ABSI) calculated by using waist circumference (WC) adjusted for height and weight could improve the predictive performances for cardiovascular disease (CVD) of the Framingham's general CVD algorithm and to compare its predictive performances with other anthropometric measures.

Methods: We analyzed data on a 10-year population-based follow-up of 8,248 (4,471 women) individuals aged ≥30 years, free of CVD at baseline. CVD risk was estimated for a 1 SD increment in ABSI, body mass index (BMI), waist-to-hip ratio (WHpR) and waist-to-height ratio (WHtR), by incorporating them, one at a time, into multivariate accelerated failure time models.

A cross sectional study on prevalence and etiology of syncope in Tehran.

Recurrent syncope of obscure etiology, particularly in those with structural heart diseases, is associated with higher mortality rates. There are insufficient and conflicting data on prevalence and etiology of syncope in the urban Middle Eastern population. Evaluating the etiologic basis of syncope can be an effective step in prevention of morbidities and sudden cardiac death in susceptible populations.

Value of exercise tolerance testing in evaluation of diabetic patients presented with atypical chest discomfort.

Background: Coronary artery disease is the single most important cause of mortality and morbidity in diabetic patients. Electrocardiographic stress test is a non-invasive modality to screen significant coronary involvement in minimally symptomatic diabetics.

Objectives: We investigated the Positive Predictive Value (PPV) of this test in comparison with coronary angiography.

Sudden cardiac death as a result of neglected hypopituitarism.

Cardiac involvement infrequently occurs in hypopituitarism, and lethal cardiac arrhythmias are rarely reported. We present a middle age female who died as a consequence of refractory ventricular arrhythmia whose medical history and previous laboratory investigation were consistent with hypopituitarism. We conclude that hypopituitarism may lead to electrocardiographic changes and malignant ventricular arrhythmia and should be included in laboratory investigation and differential diagnosis of patients presenting with long QT syndrome.

Prevalence of QTc interval changes in acute psychiatric care: a cross-sectional study.

Introduction: In a case series we examined the prevalence and incidence of QT changes during a 1-week interval in hospitalized patients in a general psychiatry ward during a 6-month period.

Method: This cross-sectional study was done on electrocardiographic QT interval of patients admitted to the Psychiatric Department of Taleghani Hospital during a 6-month period excluding subjects with underlying cause of QT prolongation.

Results: Admission and follow-up electrocardiograms of 27 men and 47 women were studied, there was significant QT prolongation during hospitalization (P value 0.

Lipid profile components and incident cerebrovascular events versus coronary heart disease; the result of 9 years follow-up in Tehran Lipid and Glucose Study.

Objective: To assess the effects of lipid component total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and non-HDL-C on risk of stroke events versus coronary heart disease (CHD).

Methods: The study was conducted on 2620 Iranians, aged ≥ 50 years, free from cardiovascular events at baseline (1999-2001). The multivariable hazard ratios (HRs) for stroke/CHD were calculated for 1 mmol/L change in lipid components, using Cox proportional hazard regression.

Isolated post-challenge hyperglycaemia and risk of cardiovascular events: Tehran Lipid and Glucose Study.

Objective: To evaluate the risk of cardiovascular events in diabetes defined by isolated post-challenge hyperglycaemia (IPH).

Methods: We followed 3794 subjects aged ≥40 years without known history of diabetes or cardiovascular disease (CVD) at baseline for CVD events. Participants were categorized as subjects without diabetes [fasting plasma glucose (FPG) < 126 mg/dL and 2-h post-challenge plasma glucose (2-hPG) < 200 mg/dL], IPH (FPG < 126 mg/dL and 2-h PG ≥ 200 mg/dL) and fasting hyperglycaemia (fasting blood glucose (FBS) ≥ 126 mg/dL).

Sudden cardiac death after treatment with low dose risperidone in combination with cotrimoxazole.

Unlabelled: Risperidone as an antipsychotic drug raises the risk of serious ventricular tachyarrhythmias and sudden cardiac death; co-administered with other potentially arrhythmogenic drugs the risk escalates. There are some electrocardiographic markers which may help predict such events.

Case Report: We describe a 47-year-old woman with acute psychosis, who died suddenly subsequent to refractory ventricular arrhythmia, while on low dose risperidone combined with cotrimoxazole.

Adult height and risk of coronary heart disease: Tehran Lipid and Glucose Study.

Background: We assessed the relationship between height and coronary heart disease (CHD) in an urban population of Tehran.

Methods: 4110 participants of the Tehran Lipid and Glucose Study who were 40 years of age or older (1880 men and 2230 women; mean age, 55.1 and 53.

Association of educational status with cardiovascular disease: Teheran Lipid and Glucose Study.

Objective: The aim of this study was to evaluate the associations between educational level and cardiovascular disease (CVD) in an older Iranian population.

Methods: To estimate the odds ratio (OR) of educational level in a cross-sectional study, logistic regression analysis was used on 1,788 men and 2,204 women (222 men and 204 women positive based on their CVD status) aged ≥ 45 years.

Results: In men, educational levels of college degree and literacy level below diploma were inversely associated with CVD in the multivariate model [0.

Clinical features of hepatopulmonary syndrome in cirrhotic patients.

Aim: To evaluate the frequency, clinical and paraclinical features of hepatopulmonary syndrome (HPS) and to determine their predictive values in diagnosis of this syndrome in patients in Iran.

Methods: Fifty four cirrhotic patients underwent contrast enhanced echocardiography to detect intrapulmonary and intracardiac shunts by two cardiologists. Arterial blood oxygen, O(2) gradient (A-a) and orthodoxy were measured by arterial blood gas (ABG) test.