Mechanophysical-chemotherapy combinations: a dual approach to combat cancer.

Cancer treatment, owing to its myriad limitations, has often been a formidable challenge to both the practitioners as well as researchers. There has been a continued effort in designing newer and successful strategies to obtain optimal results. One such strategy includes the elucidation of a combinatorial approach of the conventional chemotherapy protocol with various mechanophysical methods.

Solid self-nanoemulsifying delivery systems as a platform technology for formulation of poorly soluble drugs.

New drug discovery programs produce molecules with poor physico-chemical properties, making delivery of these molecules at the right proportion into the body a big challenge to the formulation scientist. The various options available to overcome the hurdle include solvent precipitation, micronisation/nanonization using high-pressure homogenization or jet milling, salt formation, use of microspheres, solid dispersions, cogrinding, complexation, and many others. Self-nanoemulsifying systems (SNES) form one of the most popular and commercially viable approaches for delivery of poorly soluble drugs exhibiting dissolution rate limited absorption, especially those belonging to the Biopharmaceutics Classification System II/IV.