Publications by authors named "Farha Husain"
is a prevalent fungal pathogen of humans. Understanding the development of decreased susceptibility to ECN drugs of this microbe is of substantial interest, as it is viewed as an intermediate step allowing the formation of resistance mutations. We used six previously characterized mutants that decreased caspofungin susceptibility either by acquiring aneuploidy of chromosome 5 (Ch5) or by aneuploidy-independent mechanisms.
View Article and Find Full Text PDFAdaptation to ER stress is linked to the pathogenicity of . The fungus responds to ER stress primarily by activating the conserved Ire1-Hac1-dependent unfolded protein response (UPR) pathway. Subsequently, when ER homeostasis is re-established, the UPR is attenuated in a timely manner, a facet that is unexplored in .
View Article and Find Full Text PDFArticle Synopsis
- Fungal pathogens like Candida albicans have developed various survival strategies to resist antifungal treatments and successfully invade host tissues, highlighting the need for deeper understanding of their mechanisms.
- The study focuses on Rta3, a unique protein in fungi that plays a critical role in maintaining mitochondrial energy levels and aiding resistance to the antifungal miltefosine while influencing the movement of phosphatidylcholine across the plasma membrane.
- Findings suggest that Rta3 is crucial for biofilm development regulated by Bcr1, with Rta3 affecting gene expression related to cell adhesion and growth, indicating its significance in the pathogenicity of C. albicans.