Publications by authors named "Fares Alken"

Article Synopsis
  • Bipolar radiofrequency ablation (B-RFA) is a treatment for heart problems when other therapies don't work.
  • A study found it was effective in many patients with serious heart issues, and most had good results after the treatment.
  • Combining different types of B-RFA techniques helped make bigger lesions, which is better for treatment, but some complications can happen.
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BACKGROUND Recent evidence indicates that sympathetic/parasympathetic coactivation (CoA) is causally linked to changes in heart rate (HR) dynamics. Whether this is relevant for patients with atrial fibrillation (AF) is unknown. MATERIAL AND METHODS In patients with paroxysmal AF (n=26) and age-matched controls, (n=10) we investigated basal autonomic outflow and HR dynamics during separate sympathetic (cold hand immersion) and parasympathetic activation (O2-inhalation), as well as during CoA (cold face test).

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The parasympathetic nervous system plays an important role in the pathophysiology of atrial fibrillation. Catheter ablation, a minimally invasive procedure deactivating abnormal firing cardiac tissue, is increasingly becoming the therapy of choice for atrial fibrillation. This is inevitably associated with the obliteration of cardiac cholinergic neurons.

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