Antibiotic Use Without a Prescription: A Multisite Survey of Patient, Health System, and Encounter Characteristics.

Background: Using antibiotics without a prescription is potentially unsafe and may increase the risk of antimicrobial resistance. We evaluated the effect of patient, health system, and clinical encounter factors on intention to use antibiotics without a prescription that were (1) purchased in the United States, (2) obtained from friends or relatives, (3) purchased abroad, or (4) from any of these sources.

Methods: The survey was performed January 2020-June 2021 in 6 publicly funded primary care clinics and 2 private emergency departments in Texas, United States.

Erratum: Identifying symptoms/illnesses and situations that predispose outpatients to use antibiotics in two healthcare systems - CORRIGENDUM.

[This corrects the article DOI: 10.1017/ash.2022.

Endoplasmic reticulum stress induces degradation of glucose transporter proteins during hyperglycemic hepatotoxicity: Role of PERK-eIF2α-ATF4 axis.

Hyperglycemia induced reactive oxygen species oxidize macromolecules including cellular proteins leading to their accumulation in Endoplasmic Reticulum (ER) lumen which in turn activates unfolded protein response (UPR) sensors including, PERK (Protein Kinase RNA-Like ER Kinase). Activated PERK induces ER associated degradation of misfolded proteins to lower the ER stress. In the present study, we hypothesized that ER stress leads to the degradation of glucose transporter proteins resulting in complex glucose metabolism.

Outcomes of preoperative antiplatelet therapy in patients with acute type A aortic dissection.

Background: Acute type A aortic dissection (ATAAD) is life-threatening and requires immediate surgery. Sudden chest pain may lead to a risk of misdiagnosis as an acute coronary syndrome and may lead to subsequent antiplatelet therapy (APT). We used the Chinese Acute Aortic Syndrome (AAS) Collaboration Database to study the effects of APT on clinical outcomes.

Case-based audit and feedback around a decision aid improved antibiotic choice and duration for uncomplicated cystitis in primary care clinics.

Objectives: The objective of our study was to evaluate the impact of a multifaceted stewardship intervention on adherence to the evidence-based practice guidelines on treatment of uncomplicated cystitis in primary care. We hypothesised that our intervention would increase guideline adherence in terms of antibiotic choice and duration of treatment.

Design: A preintervention and postintervention comparison with a contemporaneous control group was performed.

Uptake, accumulation and elimination of cadmium in a soil - Faba bean (Vicia faba) - Aphid (Aphis fabae) - Ladybird (Coccinella transversalis) food chain.

Cadmium is a highly mobile toxic heavy metal and a serious hazard to the biosphere. We studied uptake, accumulation and elimination of cadmium in a soil - faba bean - aphid - ladybird food chain. The soil in the study was amended with Cd at concentrations 0, 5, 10, 20 and, 30 mg kg (w/w).

Interaction of ZnO nanoparticle and AM fungi mitigates Pb toxicity in wheat by upregulating antioxidants and restricted uptake of Pb.

The study aims at investigating the efficacy of individual as well as combined application of AM fungi (Glomus macrocarpum) and ZnO nanoparticles on the uptake of lead and its toxicity in wheat (Triticum aestivum L.). The plants were grown in pots with different treatments of AM Fungi, ZnO NP, and Pb.

Validating Use of Electronic Health Data to Identify Patients with Urinary Tract Infections in Outpatient Settings.

Objective: To validate the use of electronic algorithms based on International Classification of Diseases (ICD)-10 codes to identify outpatient visits for urinary tract infections (UTI), one of the most common reasons for antibiotic prescriptions.

Methods: ICD-10 symptom codes (e.g.

Aortic and mitral valve surgery for infective endocarditis with reconstruction of the intervalvular fibrous body: an analysis of clinical outcomes.

Background: Reconstruction of the aorto-mitral curtain (AMC) for invasive double-valve infective endocarditis (IE) is a rare and challenging procedure. This study presents the short- and mid-term results of reconstruction of AMC in a single center.

Methods: From 2016 to 2019, 14 patients with invasive double-valve underwent surgical reconstruction of the AMC, along with either double valve replacement or aortic valve replacement with mitral valve repair.

Qualitative Analysis of Primary Care Provider Prescribing Decisions for Urinary Tract Infections.

Inappropriate choices and durations of therapy for urinary tract infections (UTI) are a common and widespread problem. In this qualitative study, we sought to understand why primary care providers (PCPs) choose certain antibiotics or durations of treatment and the sources of information they rely upon to guide antibiotic-prescribing decisions. We conducted semi-structured interviews with 18 PCPs in two family medicine clinics focused on antibiotic-prescribing decisions for UTIs.

Assessment of biotransfer and bioaccumulation of cadmium, lead and zinc from fly ash amended soil in mustard-aphid-beetle food chain.

The present study investigates the extent of biotransfer and bioaccumulation of cadmium (Cd), lead (Pb) and zinc (Zn) from fly ash amended soil in mustard (Brassica juncea)-aphid (Lipaphis erysimi)-beetle (Coccinella septempunctata) food chain and its subsequent implications for the beetle. The soil was amended with fly ash at the rates of 0, 5, 10, 20 and 40% (w/w). Our results showed that the uptake of Cd, Pb and Zn from soil to mustard root increased with the increase in fly ash application rates, but their root to shoot translocation was relatively restricted.

Evaluating efficacy of various operative procedures done in anterior urethral stricture using urethral stricture score.

Context: Scoring systems have been an important tool of clinical decision making in medicine. As scoring systems like Glasgow Coma scale have made a revolutionary change in stratifying the patient, in particular, clinical scenario. Wiegand et al.

The transfer and fate of Pb from sewage sludge amended soil in a multi-trophic food chain: a comparison with the labile elements Cd and Zn.

The contamination of agroecosystems due to the presence of trace elements in commonly used agricultural materials is a serious issue. The most contaminated material is usually sewage sludge, and the sustainable use of this material within agriculture is a major concern. This study addresses a key issue in this respect, the fate of trace metals applied to soil in food chains.

A brief overview of preeclampsia.

Preeclampsia (PE) is a leading cause of maternal mortality and morbidity worldwide. It occurs in women with first or multiple pregnancies and is characterized by new onset hypertension and proteinuria. Improper placentation is mainly responsible for the disease.

Single-stage preputial skin flap urethroplasty for long-segment urethral strictures: evaluation and determinants of success.

Objective: To determine the overall efficacy and predictors of success of the penile preputial flap in the management of complex urethral strictures >2.5 cm in length.

Patients And Methods: We performed a retrospective and prospective study of 58 patients undergoing single-stage penile preputial flap urethroplasty for complex long-segment urethral strictures, without lichen sclerosus, repaired between May 2005 and April 2012 at our institution.

Comprehensive analysis of etiology on the prognosis of urethral strictures.

Introduction: Urethral strictures remain a reconstructive dilemma, due to high incidence of recurrence and less than satisfactory outcomes. Even experienced surgeons following strict surgical principles have not achieved optimal results, leading us to think whether the etiology of strictures dictate the outcome . We evaluated this "cause-effect" relationship highlighting the significance of the etiology on the overall prognosis of urethral strictures.

Prognosis of urethral strictures following pelvic fracture urethral distraction defects--a single centre study.

Introduction: Urethral strictures remain a reconstructive dilemma due to high incidence of recurrence and unsatisfactory outcomes. Pelvic trauma remains the foremost etiology leading to morbidity. We evaluated this "cause-effect" relationship of pelvic trauma to stricture outcome, to replenish our understanding of contemporary urethral strictures and highlight significance of type, degree and influence of primary management of pelvic trauma on the overall prognosis of urethral strictures.