Effect of alemtuzumab on fatigue, quality of life, and patient/caregiver-reported outcomes in relapsing-remitting multiple sclerosis-A real-world evidence study.

Background: Alemtuzumab is approved in the European Union for treating highly active relapsing-remitting multiple sclerosis (RRMS). Patient-reported outcomes measure the treatment impact on quality of life (QoL), including fatigue, a common symptom in multiple sclerosis (MS). Chronic diseases like MS also affect the patient's caregiver.

Predicting Epileptic Seizures Using Biometric Sensors - A Pilot Study Protocol.

Epilepsy is a prevalent neurological disorder characterized by unpredictable seizures despite some known risk factors. Using an mHealth system and Empatica EmbracePlus, we aim to examine if biometric sensor data can detect and predict epileptic seizures. Five participants with epilepsy will be followed for a minimum of 15 seizures.

Towards Automatic Migraine-Event Prediction Using Continuous Sensor Data.

Migraine is a chronic headache disorder. A prototype mobile app-based system was implemented to test data collection and improve data coverage for the Empatica E4 biometric sensor device. Results from the prototype testing are reported.

Educational patterning in biological health seven years apart: Findings from the Tromsø Study.

Background: Social-to-biological processes is one set of mechanisms underlying the relationship between social position and health. However, very few studies have focused on the relationship between social factors and biology at multiple time points. This work investigates the relationship between education and the dynamic changes in a composite Biological Health Score (BHS) using two time points seven years apart in a Norwegian adult population.

Impact of extent of resection on outcome from glioblastoma using the RANO resect group classification system: a retrospective, population-based cohort study.

Background: Extent of resection (EOR) is associated with survival in glioblastoma. A standardized classification for EOR was lacking until a system was recently proposed by the response assessment in neuro-oncology (RANO) resect group. We aimed to assess EOR in an unselected glioblastoma cohort and use this classification system to evaluate the impact on survival in a real-world setting.

The level of health anxiety before and during the COVID-19 pandemic.

Background: Concerns about disease and an increase in health anxiety levels are expected consequences of the COVID-19 pandemic. However, there have been few longitudinal studies of health anxiety in the general population during this time period. The aim of this study was to examine health anxiety levels before and during the COVID-19 pandemic in an adult, working population in Norway.

Cold exposure and musculoskeletal conditions; A scoping review.

Musculoskeletal conditions are major contributors to years lived with disability. Cold exposure can be a risk factor, but any conclusion is obscure. The aim of the present scoping review was to identify the existing evidence of an association between cold exposure and musculoskeletal conditions.

Butterfly glioblastoma: Clinical characteristics, treatment strategies and outcomes in a population-based cohort.

Background: Butterfly glioblastoma is a rare subgroup of glioblastoma with a bihemispheric tumor crossing the corpus callosum, and is associated with a dismal prognosis. Prognostic factors are previously sparsely described and optimal treatment remains uncertain. We aimed to analyze clinical characteristics, treatment strategies, and outcomes from butterfly glioblastoma in a real-world setting.

CSF neurofilament light chain predicts 10-year clinical and radiologic worsening in multiple sclerosis.

Background: Neurofilament light chain (NfL) is an attractive biomarker of disease activity and progression in MS, but there is a lack in long-term prognostic data.

Objective: To test the long-term clinical and radiological prognostic value of cerebrospinal fluid (CSF)-NfL among newly diagnosed patients with MS.

Methods: Newly diagnosed MS patients where followed prospectively with baseline CSF-NfL and repeated MRI and clinical assessments for up to 10 years.

To tolerate weather and to tolerate pain: two sides of the same coin? The Tromsø Study 7.

It is a common belief that weather affects pain. Therefore, we hypothesized that weather can affect pain tolerance. This study used data from over 18,000 subjects aged 40 years or older from the general population, who participated in the Tromsø Study 7.

Treatment approach and survival from glioblastoma: results from a population-based retrospective cohort study from Western Norway.

Objectives: To evaluate treatment and survival from glioblastoma in a real-world setting.

Design And Settings: A population-based retrospective cohort study from Western Norway.

Participants: 363 patients aged 18 years or older diagnosed with glioblastoma between 1 January 2007 and 31 December 2014.

Brain atrophy and clinical characteristics predicting SDMT performance in multiple sclerosis: A 10-year follow-up study.

Objectives: To identify Magnetic Resonance Imaging (MRI), clinical and demographic biomarkers predictive of worsening information processing speed (IPS) as measured by Symbol Digit Modalities Test (SDMT).

Methods: Demographic, clinical data and 1.5 T MRI scans were collected in 76 patients at time of inclusion, and after 5 and 10 years.

Is working in a cold environment associated with musculoskeletal complaints 7-8 years later? A longitudinal analysis from the Tromsø Study.

Objective: Exposure to a cold environment at work is associated with a higher prevalence of musculoskeletal pain and chronic pain in cross-sectional studies. This study aims to determine the association between working in a cold environment ≥ 25% of the time and musculoskeletal complaints (MSC) 7-8 years later.

Methods: We followed participants from the sixth survey (Tromsø 6, 2007-2008) to the seventh survey (Tromsø 7, 2015-2016) of the Tromsø Study.

Brain atrophy and employment in multiple sclerosis patients: a 10-year follow-up study.

Background: Multiple sclerosis is often associated with unemployment. The contribution of grey matter atrophy to unemployment is unclear.

Objectives: To identify magnetic resonance imaging biomarkers of grey matter and clinical symptoms associated with unemployment in multiple sclerosis patients.

Gut microbiota composition during a 12-week intervention with delayed-release dimethyl fumarate in multiple sclerosis - a pilot trial.

Introduction: Patients with multiple sclerosis may have a distinct gut microbiota profile. Delayed-release dimethyl fumarate is an orally administered drug for relapsing-remitting multiple sclerosis, which has been associated with gastrointestinal side-effects in some patients.

Objectives: The purpose of this study was to determine if dimethyl fumarate alters the abundance and diversity of commensal gut bacteria, and if these changes are associated with gastrointestinal side-effects.

Working in a cold environment, feeling cold at work and chronic pain: a cross-sectional analysis of the Tromsø Study.

Aim: The aim of this study was to investigate if working in a cold environment and feeling cold at work are associated with chronic pain (ie, lasting ≥3 months).

Methods: We used data from the sixth survey (2007-2008) of the Tromsø Study. Analyses included 6533 men and women aged 30-67 years who were not retired, not receiving full-time disability benefits and had no missing values.

Neurofilaments and 10-year follow-up in multiple sclerosis.

Background: The role of biomarkers to predict clinical outcome in multiple sclerosis (MS) is still debated.

Objective: To test whether cerebrospinal fluid (CSF) light-chain neurofilament (NfL) levels in newly diagnosed patients with MS could predict clinical outcome over a 10-year period.

Methods: Patients with newly diagnosed MS underwent standardized clinical assessments at baseline and 5 and 10 years of follow-up.

Aerodynamic evaluation of the empty nose syndrome by means of computational fluid dynamics.

The potential outcome of a surgical enlargement of internal nasal channels may be a complication of nasal breathing termed the Empty Nose Syndrome (ENS). ENS pathophysiology is not entirely understood because the expansion of air pathways would in theory ease inhalation. The present contribution is aimed at defining the biophysical markers responsible for ENS.

Wake-up stroke-Amendable for thrombolysis-like stroke with known onset time?

Patients suffering an acute ischemic stroke can be treated with intravenous thrombolysis in the absence of contraindications. A known onset time is a prerequisite as treatment, according to guidelines, has to be started within 4.5 hours.

The influence of coping styles on long-term employment in multiple sclerosis: A prospective study.

Background: The aim was to investigate predictive values of coping styles, clinical and demographic factors on time to unemployment in patients diagnosed with multiple sclerosis (MS) during 1998-2002 in Norway.

Method: All patients ( N = 108) diagnosed with MS 1998-2002 in Hordaland and Rogaland counties, Western Norway, were invited to participate in the long-term follow-up study in 2002. Baseline recordings included disability scoring (Expanded Disability Status Scale (EDSS)), fatigue (Fatigue Severity Scale (FSS)), depression (Beck Depression Inventory (BDI)), and questionnaire assessing coping (the Dispositional Coping Styles Scale (COPE)).

Preclinical disease activity in multiple sclerosis: A prospective study of cognitive performance prior to first symptom.

Objective: To prospectively investigate potential signs of preclinical multiple sclerosis (MS) activity and when they are present prior to first symptom using data from a historical cohort.

Methods: We linked the cognitive performance of all Norwegian men born 1950-1995 who underwent conscription examination at age 18 to 19 years to the Norwegian MS registry to identify those later developing MS, and randomly selected controls frequency-matched on year of birth from the Norwegian Conscript Service database. In this nested case-control study, cognitive test scores were available for 924 male cases and 19,530 male controls.

Guillain Barré syndrome--Incidence and clinical course in Southern Rogaland, Norway.

Objective: To establish the incidence and clinical course of Guillain Barré syndrome (GBS) in a well-defined geographical area.

Patients And Methods: All patients older than 16 years of age diagnosed with GBS were prospectively invited to join a follow-up study for two years.

Results: Seventeen patients were diagnosed with GBS; an incidence rate of 2.

Radiological imaging in acute ischaemic stroke.

Patients who suffer acute ischaemic stroke can be treated with thrombolysis if therapy is initiated early. Radiological evaluation of the intracranial tissue before such therapy can be given is mandatory. In this review current radiological diagnostic strategies are discussed for this patient group.