The main aim of this study is to synthesize contrast microbubbles (MB) functionalized with engineered protein ligands using a microfluidic device to target breast cancer specific vascular B7-H3 receptor in vivo for diagnostic ultrasound imaging. We used a high-affinity affibody (ABY) selected against human/mouse B7-H3 receptor for engineering targeted MBs (TMBs). We introduced a C-terminal cysteine residue to this ABY ligand for facilitating site-specific conjugation to DSPE-PEG-2K-maleimide (M.
View Article and Find Full Text PDFRecently, 3D/4D printing technologies have been the researchers' interest, and they are getting improved more important. They are applicable in various fields like medical fields, pharmaceutics, construction, tissue engineering, dentistry, water treatment, etc. These technologies overcame the difficulty of the conventional methods in producing complicated structures.
View Article and Find Full Text PDFToday, hydrogels opened new windows to the high-tech due to their amazing features. Thus, we applied hydrogel nanocomposite (HNC) made of tragacanth gum (a kind of polysaccharide) and CaCO nanoparticles to remove methylene blue dye (MBD) from the water solution. We used nonlinear and linear isotherms and kinetics as well as thermodynamics to uncover the adsorption mechanism.
View Article and Find Full Text PDFThe world and science are moving forward nonstop. Every day, we see novel technologies that are coming to improve life quality. One of them is 3D printing or additive manufacturing.
View Article and Find Full Text PDFThis study aims to prepare a hydrogel bionanocomposite (HBNC) as an efficient adsorbent and introduce it as a suitable replacement for petroleum-based adsorbents. Thus, tragacanth gum (TG), and carboxyl-functionalized carbon nanotube (CFCNT) were used as raw materials. HBNCs were prepared with the aid of ultrasonication, and different methods were employed to characterize them.
View Article and Find Full Text PDFIn the current work, novel eco-friendly hydrogel nanocomposite biosorbents (ef-HNCs) made up from tragacanth gum and modified CaCO nanoparticles (CC NPs) were applied for the adsorption of methylene blue dye (MBD). A simple, fast, and safe method regarding green chemistry was used to prepare the ef-HNC, with the aid of ultrasound waves. The ef-HNCs were successfully characterized using several spectroscopic, microscopic, and analytical methods.
View Article and Find Full Text PDFThis article reports the first incorporation of calcium carbonate nanoparticles (CC NPs) into tragacanth gum (TG) to prepare a new hydrogel nanocomposite (HNC) system using a green, safe, and eco-friendly method, ultrasound irradiation as an efficient biosorbent of heavy metal ions from wastewater. Morphological studies revealed that the surface of obtained HNCs is rough, homogeneous, and porous-like due to the embedding of CC NPs as well as sonication in comparison to the neat TG which has a smooth surface. The particle size reduction was observed for CC NPs in the matrix (from 57 to 10 nm), which is owing to the extraordinary effect of sonication on this process.
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