Reducing Effect of Cloxacillin on Minimum Inhibitory Concentrations to Imipenem, Meropenem, Ceftazidime, and Cefepime in Carbapenem-resistant Isolates.

Today, resistance to antibacterial agents is the most important problem facing public health. is a common gram-negative bacterium and an important cause of nosocomial infections. Resistance to many antibiotics in strains of isolated from hospital settings such as cephalosporins and carbapenems have been recently reported.

Synthesis and antibacterial activity of nitroaryl thiadiazole-gatifloxacin hybrids.

A number of gatifloxacin analogues containing a nitroaryl-1,3,4-thiadiazole moiety attached to the piperazine ring at C-7 position were prepared and evaluated as antibacterial agents against a panel of gram-positive and gram-negative bacteria. Among synthesized compounds, nitrofuran analog 6a exhibited more potent inhibitory activity against gram-positive bacteria including Staphylococcus epidermidis (MIC=0.0078 microg/mL), Bacillus subtilis (MIC=0.