Characteristics, Clinical Outcomes and Healthcare Utilization of Women with Cystic Fibrosis and their Live Newborns Delivered in the Hospital Setting.

Introduction: Survival in cystic fibrosis (CF) is increasing and more women are considering their reproductive options, however there is limited data on pregnancy and neonatal outcomes in this population. The objectives of this study were to describe maternal and neonatal outcomes in women with CF and the general Canadian maternal population (general population).

Methods: Maternal and neonatal clinical outcomes and healthcare utilization for in-hospital live births was retrieved from the Canadian Institute for Health Information's Discharge Abstract Database.

Development of a Canadian Guidance for reporting real-world evidence for regulatory and health-technology assessment (HTA) decision-making.

Background And Objective: Real-world evidence (RWE) can complement and fill knowledge gaps from randomized controlled trials to assist in health-technology assessment (HTA) for regulatory decision-making. However, the generation of RWE is an intricate process with many sequential decision points, and different methods and approaches may impact the quality and reliability of evidence. Standardization and transparency in reporting these decisions is imperative to appraise RWE and incorporate it into HTA decision-making.