Carrier-free prodrug nanoparticles based on dasatinib and cisplatin for efficient antitumor .

Carrier-free drug self-delivery systems consisting of amphiphilic drug-drug conjugate (ADDC) with well-defined structure and nanoscale features have drawn much attention in tumor drug delivery. Herein, we report a simple and effective strategy to prepare ADDC using derivatives of cisplatin (CP) and dasatinib (DAS), which further self-assembled to form reduction-responsive nanoparticles (CP-DDA NPs). DAS was modified with succinic anhydride and then connected with CP derivative by ester bonds.

[Expression and role of survivin in laryngeal squamous cell carcinoma and laryngeal papilloma in adults].

Objective: To study the expression of Survivin in laryngeal squamous cell carcinoma (LSCC) and laryngeal papilloma in adults and its significance in carcinogenesis and development of the LSCC.

Method: The expressions of Survivin protein were detected by immunohistochemistry technique in 46 cases of LSCC, 24 cases of adjacent nontumorous laryngeal epithelium, 20 cases of laryngeal papilloma and 16 cases of normal laryngeal epithelium.

Result: The positive rates of Survivin protein expression in laryngeal carcinoma, adjacent nontumorous laryngeal epithelium and laryngeal papilloma were 71.

[Analysis of vertical partial laryngectomy for carcinoma of the larynx].

Objective: To evaluate the effect of vertical partial laryngectomy in the treatment of laryngocarcinoma.

Method: 50 patients who underwent vertical partial laryngectomy from 1979 to 1997 were retrospectively reviewed. The reconstruction methods for the laryngeal defect were the pedicle muscular flap, skin graft, cervical skin flap, hypopharyngeal mucous membrane flap and outer perichondrium of the thyroid cartilage etc.