Publications by authors named "Faouzi Souala"
Background: Despite an effective vaccine, hepatitis B remains a major global health problem due to its significant morbidity and mortality. Vaccination in immunosuppressed patients such as those treated for an inflammatory bowel disease (IBD) can be less effective. This case describes an uncommon original diagnosis of an acute hepatitis B infection occurring in a vaccinated but immunocompromised IBD patient under long-term infliximab treatment.
View Article and Find Full Text PDFEnhanced immunovirological response in women compared to men after antiretroviral therapy initiation during acute and early HIV-1 infection: results from a longitudinal study in the French ANRS Primo cohort.
J Int AIDS Soc
April 2020
Article Synopsis
- A study examined whether women continue to show better immune responses than men after starting long-term antiretroviral therapy (ART) for HIV, based on data from the ANRS PRIMO cohort.
- Results revealed that women had lower viral loads compared to men before starting ART and achieved viral suppression more quickly; they also demonstrated faster immune recovery as indicated by increases in CD4 T-cell counts.
- Ultimately, the findings underscore the importance of early HIV diagnosis and immediate ART initiation, suggesting that women's advantages in immune recovery persist over time, potentially offering more protection against clinical complications.
Introduction: Mitochondrial dysfunction is a classic complication of HIV infection and its treatment and has also been reported in hepatitis C virus (HCV)-infected patients. Little is known about interactions between both viruses on mitochondrial metabolism.
Methods: We performed a cross-sectional study of HCV-infected patients who underwent liver biopsy as part of their routine care.
Background: In the current context of increasing unsafe sex, HIV incidence may have evolved, depending on HIV prevalence in sexual networks and, among HIV-infected persons who practice unsafe sex, on their infectivity and partners' HIV serostatus. We examined calendar trends in sexual behaviours at risk of HIV-1 transmission (SBR) among 967 adults followed since primary HIV infection (ANRS PRIMO cohort) and relationship with current treatments and viral load.
Methods: Patients completed since 2000 self-administered questionnaires on sexual practices every 6 months.
Interferon-α administration during structured treatment interruptions (STIs) was studied in a phase III trial. We randomized 168 chronically infected HIV undetectable under combined antiretroviral therapy patients to have three STIs with or without α-interferon. The number of patients who had to resume treatment during post-STI follow-up was not significantly different between the two arms.
View Article and Find Full Text PDFBackground: Prevalence of HIV-1 non-B subtypes has increased overtime in patients diagnosed at the time of primary infection (PHI) in France. Our objective was to characterize in detail non-B strains which could not be genetically classified into the known subtypes/Circulating Recombinant Forms (CRFs).
Methods: Among 744 patients enrolled in the ANRS PRIMO Cohort since 1996, 176 (23.
From 1991 to 2003, 20 patients with pasteurellosis were admitted to our unit, of whom 2 died. They presented with cellulitis (n = 14), arthritis (n = 6), pneumonia (n = 3), subcutaneous abscess (n = 3), bursitis (n = 2), meningitis, otitis, sinusitis and uveitis. Underlying diseases included diabetes (n = 6) and malignancy (n = 5).
View Article and Find Full Text PDFMitochondrial abnormalities in HIV-infected lipoatrophic patients treated with antiretroviral agents.
J Acquir Immune Defic Syndr
December 2004
Background: Lipodystrophy is now widely described in HIV infected patients under antiretroviral regimen with important psychological impact. But physiopathology of loss of fat mass is still debated and the role of mitochondrial impairment is not clearly defined.
Objective: To correlate clinical lipoatrophy (LA) in HIV patients with long-term treatment by nucleoside reverse transcriptase inhibitors (NRTIs) and muscular impairment related to mitochondrial dysfunction.
Objectives. A retrospective multicentric study was conducted over a five-year period to evaluate the clinical and laboratory characteristics and outcome of patients with proven Pneumocystis carinii pneumonia (PCP) complicating hematologic malignancies.Results.
View Article and Find Full Text PDFThe aim of this retrospective study was to determine the underlying diseases associated with Pneumocystis carinii pneumonia (PCP) in immunocompromised HIV-negative patients and to identify prognosis factors in this population. One hundred three cases of PCP were diagnosed over a 5-year period. Diagnosis was established on the basis of clinical features and by detection of Pneumocystis carinii cysts in bronchoalveolar lavage fluid.
View Article and Find Full Text PDFObjective: To evaluate the safety profile and efficacy of salvage regimens containing amprenavir (APV) 600 mg twice daily and ritonavir (RTV) 200 mg twice daily.
Design: Prospective, single-center study.
Method: The patient database of the department of infectious diseases was screened for patients who had failed at least two successive three-drug combinations.