Publications by authors named "Fanyou Meng"
Parecoxib reduced ventilation induced lung injury in acute respiratory distress syndrome.
BMC Pharmacol Toxicol
March 2017
Background: Cyclooxygenase-2 (COX-2) contributes to ventilation induced lung injury (VILI) and acute respiratory distress syndrome (ARDS). The objective of present study was to observe the therapeutic effect of parecoxib on VILI in ARDS.
Methods: In this parallel controlled study performed at Harbin Medical University, China between January 2016 and March 2016, 24 rats were randomly allocated into sham group (S), volume ventilation group/ARDS (VA), parecoxib/volume ventilation group/ARDS (PVA).
Article Synopsis
- The study involved 62 patients experiencing massive hemorrhage, with blood samples taken at specified blood loss intervals (1000, 1500, 1700, and 2000 ml).
- Findings revealed that FIB, MAP, HGB, HCT, and PLT levels decreased significantly as blood loss increased, while PT and APTT levels rose, indicating impaired coagulation.
- The strongest correlation noted was between fibrinogen (FIB) levels and the extent of intraoperative blood loss, highlighting the critical role of FIB in monitoring coagulation under massive hemorrhage conditions.