Two-tiered subdivision of atypia on urine cytology can improve patient follow-up and optimize the utility of UroVysion.

Background: The annual incidence of urothelial carcinoma continues to increase, and it is projected that greater than 70,000 new cases will occur in the year 2015. However, as much as 23% of cytologic specimens will demonstrate some degree of atypia without meeting the criteria for urothelial carcinoma and thus will be reported as atypical.

Methods: The authors conducted 2 laboratory information searches and 1 survey.