A coordinative modular assembly-constructed self-reinforced nano-therapeutic agent for effective antitumor-immune activation.

Immunosuppressive microenvironment and poor immunogenicity are two stumbling blocks in anti-tumor immune activation. Tumor associated macrophages (TAMs) play crucial roles in immunosuppressive microenvironment, while immunogenic cell death (ICD) is a typical strategy to boost immunogenicity. Herein, we developed a coordinative modular assembly-based self-reinforced nanoparticle, (CaO/TA)-(Fe/BSA) which integrated CaO, Fe-tannic acid coordinated networks and albumin under the instruction of molecular dynamics simulation.