SEMA7A as a Novel Prognostic Biomarker and Its Correlation with Immune Infiltrates in Breast Cancer.

Background: The role of Semaphorin 7a (SEMA7A) in the initiation and progression of different types of cancerous lesions has been extensively studied. However, the prognostic significance of SEMA7A, specifically in breast cancer (BC), lacks clarity.

Methods: We conducted an evaluation on the relationship between SEMA7A and the prognosis, immune invasion and tumor mutation burden in different types of cancer by analyzing data from The Cancer Genome Atlas database.

First-principles study of the effect of oxygen vacancy and iridium doping on formaldehyde adsorption on the LaO(001) surface.

Formaldehyde adsorption on intrinsic LaO surface, four-fold coordinated oxygen vacancy (VO), six-fold coordinated oxygen vacancy (VO), and iridium-doped LaO(001) surface was studied by the first-principles method. The results show that formaldehyde adsorption on the Ir-doped LaO(001) surface with VO is the strongest because of the directional movement of electrons caused by the interaction of the Ir-5d orbitals and internal oxygen vacancy, wherein the adsorption energy is 3.23 eV.

Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer.

Metadherin (MTDH), initially discovered in primary astrocytes of the human fetus through rapid subtraction hybridization and labeled as astrocyte elevated gene-1, represents a widely recognized oncogene present in multiple types of cancers. However, the role of MTDH in different types of cancer remains unclear. To address this, a comprehensive analysis of MTDH across various types of cancers was conducted by utilizing multiple databases such as The Cancer Genome Atlas.

Association of ADP‑ribosylation factor family genes with prognosis and immune infiltration of breast cancer.

Breast cancer (BC) is the most common type of cancer found in women. ADP-ribosylation factors (ARFs) are a group of small proteins that bind to GTP and are involved in controlling different cellular functions. The function and evolution of multiple ARFs in BC have remained to be fully elucidated, despite existing studies on this protein family in and other species.

[Network Meta-analysis of different Chinese medicine injections combined with conventional western medicine in treatment of acute heart failure].

This study aims to evaluate the efficacy and safety of Chinese medicine injection in the treatment of acute heart failure. PubMed, Cochrane Library, EMbase, Web of Science, CNKI, VIP, Wanfang, and SinoMed were searched for the randomized controlled trial(RCT) of Chinese medicine injection combined with conventional western medicines in the treatment of acute heart failure with the time interval from the inception to July 10, 2023. Two researchers independently screened the literature, extracted data, and evaluated the risk of bias in the included studies.

Bioinformatic analysis reveals an association between Metadherin with breast cancer prognosis and tumor immune infiltration.

Breast cancer metastasis and invasion are both promoted by the oncoprotein Metadherin (MTDH). However, the the role of Metadherin in breast cancer progression and its role in the immune microenvironment. Are not clear.

​Efficacy and safety of pyrotinib in combination with albumin‑bound paclitaxel for the treatment of HER2‑positive advanced breast cancer: A real‑world study.

The present study aimed to determine the efficacy and safety of pyrotinib in combination with albumin-bound paclitaxel in patients with HER2-positive advanced breast cancer (ABC). A total of 48 patients diagnosed with HER2-positive ABC were included in the present study, and these patients were prescribed a combination of pyrotinib and albumin-bound paclitaxel in routine clinical practice. During a 21-day cycle, the standard dosage of pyrotinib was 400 mg single dose/day, which was administered orally, and 130 mg/m/day albumin-bound paclitaxel on days 1, 8 and 15, which was administered by intravenous drip.

LPS-pretreatment adipose-derived mesenchymal stromal cells promote wound healing in diabetic rats by improving angiogenesis.

Mesenchymal stem cells (MSCs) play a key role in wound healing, and the advantages of pretreated MSCs in wound healing have previously been reported. In the present study, we investigated the impact of LPS pretreated human adipose-derived MSCs on skin wound healing in diabetic rats. We found that some improvements occurred through improving angiogenesis.

The Value of m5C-Related lncRNAs in the Prognostic Assessment and Immunotherapy of Stomach Adenocarcinoma.

Long noncoding RNAs (lncRNAs) are closely associated with a variety of tumors, including stomach adenocarcinoma (STAD). However, the role of 5-methylcytosine- (m5C-) related lncRNAs in STAD is still uncertain. This study investigated the value of m5C-related lncRNAs in prognostic evaluation and immunotherapy of STAD.

Effect of Probiotic-Assisted Eradication of +/ on Intestinal Flora.

Objective: We attempted to evaluate the effects of probiotic-assisted eradication of - ()+/ () () on the intestinal flora, inflammatory factors, and clinical outcomes.

Methods: A total of 180 patients with +/ H were randomly divided into two groups. Group A was treated with bismuth quadruple therapy (BQT).

Clinical Effect of Clarithromycin Combined with Tinidazole on Helicobacter pylori-Related Gastritis and Its Influence on COX-2 Expression.

Studies have shown that COX-2 expression is upregulated in gastric cancer (GC) as well as in precancerous lesions and in Helicobacter pylori-induced inflammation, suggesting that cyclooxygenase-2 (COX-2) may play an important role in gastric carcinogenesis. We attempted to investigate the role of clarithromycin with tinidazole on Helicobacter pylori-related gastritis from the aspects of clinical effect and COX-2 expression. From January 2016 to January 2019, 130 patients with Helicobacter pylori-related chronic gastritis were collected and grouped into the observation group (OG) and the control group (CG).

302 W single-mode power from an Er/Yb fiber MOPA: publisher's note.

This publisher's note contains corrections to Opt. Lett.45, 2910 (2020).

302 W single-mode power from an Er/Yb fiber MOPA.

There has been very little progress in the power scaling of Er/Yb fiber lasers in over a decade, reflecting the difficulties involved. Here we report, to the best of our knowledge, a new record of 302 W single-mode power from an Er/Yb fiber master oscillator power amplifier (MOPA) with a record optical efficiency of 56%, near the quantum limit. This is made possible by new fiber development from Nufern and off-resonant pumping of the Er/Yb fiber.

Predictive factors for lymph node metastasis and defining a subgroup treatable for laparoscopic lymph node dissection after endoscopic submucosal dissection in poorly differentiated early gastric cancer.

Aim: To investigate the predictive factors of lymph node metastasis (LNM) in poorly differentiated early gastric cancer (EGC); to guide the individual application of a combination of endoscopic submucosal dissection (ESD) and laparoscopic lymph node dissection (LLND) in a suitable subgroup of patients with poorly differentiated EGC.

Methods: We retrospectively analyzed 138 patients with poorly differentiated EGC who underwent gastrectomy with lymphadenectomy between January 1990 and December 2015. The association between the clinicopathological factors and the presence of LNM was retrospectively analyzed by univariate and multivariate logistic regression analyses.

Efficient 240W single-mode 1018nm laser from an Ytterbium-doped 50/400µm all-solid photonic bandgap fiber.

Lowering the quantum defect by tandem pumping with fiber lasers at 1018nm was critical for achieving the record 10kW single-mode ytterbium fiber laser. Here we report the demonstration of an efficient directly-diode-pumped single-mode ytterbium fiber laser with 240W at 1018nm. The key for the combination of high efficiency, high power and single-mode at 1018nm is an ytterbium-doped 50μm/400μm all-solid photonic bandgap fiber, which has a practical all-solid design and a pump cladding much larger than those used in previous demonstrations of single-mode 1018nm ytterbium fiber lasers, enabling higher pump powers.

Large-mode-area fibers operating near single-mode regime.

Lower NA in large-mode-area fibers enables better single-mode operation and larger core diameters. Fiber NA has traditionally been limited to 0.06, mostly due to the control tolerance in the fabrication process.

400-W near diffraction-limited single-frequency all-solid photonic bandgap fiber amplifier.

An ytterbium-doped large-mode area photonic bandgap fiber is used to demonstrate 400 W of single-frequency output at 1064 nm with excellent beam quality and minimal stimulated Brillouin scattering. The fiber possesses all-solid microstructures embedded in the cladding and a core composed of phosphosilicate with a diameter of ∼50  μm. As the signal power is pushed beyond 450 W, there is degradation in the beam quality due to the modal instability.

Highly efficient ytterbium-doped phosphosilicate fiber lasers operating below 1020 nm.

Highly-efficient high-power fiber lasers operating at wavelength below 1020 nm are critical for tandem-pumping in >10 kW fiber lasers to provide high pump brightness and low thermal loading. Using an ytterbium-doped-phosphosilicate double-clad leakage-channel fiber with ~50 µm core and ~420 µm cladding, we have achieved ~70% optical-to-optical efficiency at 1018 nm. The much larger cladding than those in previous reports demonstrates the much lower required pump brightness, a key for efficient kW operation.

Extending mode areas of single-mode all-solid photonic bandgap fibers.

Mode area scaling of optical fiber is highly desirable for high power fiber laser applications. It is well known that incorporation of additional smaller cores in the cladding can be used to resonantly out-couple higher-order modes from a main core to suppress higher-order-mode propagation in the main core. Using a novel design with multiple coupled smaller cores in the cladding, we have successfully demonstrated a single-mode photonic bandgap fiber with record effective mode area of ~2650µm(2).

Polarizing ytterbium-doped all-solid photonic bandgap fiber with ~1150µm(2) effective mode area.

We demonstrate an Yb-doped polarizing all-solid photonic bandgap fiber for single-polarization and single-mode operation with an effective mode area of ~1150µm(2), a record for all-solid photonic bandgap fibers. The differential polarization mode loss is measured to be >5dB/m over the entire transmission band with a 160nm bandwidth and >15dB/m on the short wavelength edge of the band. A 2.

Quantitative mode quality characterization of fibers with extremely large mode areas by matched white-light interferometry.

Quantitative mode characterization of fibers with cores much beyond 50µm is difficult with existing techniques due to the combined effects of smaller intermodal group delays and dispersions. We demonstrate, for the first time, a new method using a matched white-light interferometry (MWI) to cancel fiber dispersion and achieve finer temporal resolution, demonstrating ~20fs temporal resolution in intermodal delays, i.e.

Ytterbium-doped large-mode-area all-solid photonic bandgap fiber lasers.

Single-mode operation in a large-mode-area fiber laser is highly desired for power scaling. We have, for the first time, demonstrated a 50μm-core-diameter Yb-doped all-solid photonic bandgap fiber laser with a mode area over 4 times that of the previous demonstration. 75W output power has been generated with a diffraction-limited beam and an efficiency of 70% relative to the launched pump power.

Expression of neddylation-related proteins in melanoma cell lines and the effect of neddylation on melanoma proliferation.

Neddylation promotes the process of ubiquitination, which plays a critical role in the degradation of numerous proteins, including cell cycle and apoptosis regulators. In our previous study, an increase in neddylation was identified in melanoma cell lines. In the present study, the upregulation of neddylation was detected in melanoma tissues which confirmed the results of our previous study on melanoma cell lines.

Flat-top mode from a 50 µm-core Yb-doped leakage channel fiber.

We demonstrate for the first time a flat-top mode from a 50 µm-core Yb-doped leakage channel fiber (LCF). The flat intensity distribution leads to an effective mode area of ~1880 µm(2) in the straight fiber, an over 50% increase comparing to that of regular LCF with the same core diameter. The flat-top mode was achieved by using a uniform Yb-doped silica glass in the core center with an index of ~2 × 10(-4) lower than that of the silica background.

Impact of fiber outer boundaries on leaky mode losses in leakage channel fibers.

In a leakage channel fiber, the desired fundamental mode (FM) has negligible waveguide loss. Higher-order modes (HOM) are designed to have much higher waveguide losses so that they are practically eliminated during propagation. Coherent reflection at the fiber outer boundary can lead to additional confinement especially for highly leaky HOM, leading to lower HOM losses than what are predicted by conventional FEM mode solver considering infinite cladding.