Pneumoperitoneum, pneumomediastinum and subcutaneous emphysema following argon plasma coagulation treatment of colonic angioectasia.

Introduction: The paper presents unusual symptoms as a complication of therapeutic colonoscopy.

Case Report: A 70-year-old polymorbid female patient in chronic dialysis program underwent argon plasma coagulation treatment of leaking angioectasias in the cecum and ascending colon. Shortly after the procedure she presented with shortness of breath and subcutaneous emphysema of the neck which was initially misdiagnosed as swelling.

A Young Adult with White Matter Changes and Recurrent Stroke Symptoms.

White matter changes on MRI can be a diagnostic puzzle as a large group of inflammatory, autoimmune, infectious, and neoplastic conditions can present in this way. An otherwise healthy 36-year-old male presented with his second episode of unilateral weakness, the first episode occurring five years previously. He did not have sensory or cerebellar symptoms with the current or previous episode.

Stroke Nurse Triage: Effects on Time Metrics at a Regional Stroke Center.

Introduction: Optimization of time metrics in the management of acute stroke is a priority. Nurses with special training in stroke management may contribute to enhanced delivery of care. This study analyzes the effects of initiating a nurse-led stroke triage program at a regional stroke center on time metrics of acute stroke.

The evolution of clinical outcomes in metastatic pancreatic adenocarcinoma: a 10-year experience at a tertiary referral center.

Background: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer mortality in the US. Recent studies have demonstrated survival benefits for FOLFIRINOX (5-FU, leucovorin, irinotecan, and oxaliplatin) and Gem/nab-P (gemcitabine/nab-paclitaxel) over gemcitabine. We aimed to evaluate the clinical outcomes of mPDAC before and after incorporating these newer regimens into the clinical practice.

Postpneumonectomy MRSA empyema treated with vacuum therapy - case report and literature review.

Introduction: Postpneumonectomy empyema is one of serious complications with high mortality and lethality. In this paper, the authors describe the treatment of methicillin-resistant Staphylococcus aureus-induced postpneumonectomy empyema by vacuum therapy in a patient operated on for malignant pleural mesothelioma.

Case Report: A 64-year-old patient was operated on at our clinic for epithelioid mesothelioma of the right pleural cavity.

New treatment modalities in the early stage and locally advanced non-small cell lung cancer.

The lung cancer dia-gnosis is still connected with high mortality. Even the new anticancer drugs are not able to preserve long survival in the advanced lung cancer patients. Only a minority of patients is diagnosed with early or locally advanced stages.

Two centuries of forest succession, and 30 years of vegetation changes in permanent plots in an inland sand dune area, The Netherlands.

There are not many sites in densely populated temperate Europe where primary forest succession has a chance to run without direct human intervention for a long time and over a relatively large area. The extensive drift sand area of the Veluwe, central Netherlands, provided an opportunity to study succession in a formerly open and dynamic inland sand dune system combining chronosequence and permanent plot approaches. Different successional stages, aged up to 205 years since the first tree individuals established, were identified and vegetation studied using 1200 permanent plots established in 1988 in three adjacent sand dune complexes of different successional age, and resampled during the past three decades.

Pulmonary metastases in pseudomyxoma peritonei - case report and review of the literature.

Pseudomyxoma peritonei is a rare disease caused by dissemination of cancer forming mucous and gelatinous masses in the peritoneal cavity. Local recurrence is frequent; however, dissemination outside the peritoneal cavity is rare.  Case report: We present the case report of a female patient treated for bilateral pulmonary metastases from pseudomyxoma peritonei.

Splenic abscess as a rare symptom of the extrapulmonary tuberculosis - case report.

Introduction: Extrapulmonary tuberculosis can involve any organ or tissue. It is a rare disease in the Czech Republic with an incidence rate of 0.62 cases per 100.

[Double incision laparoscopic surgery].

Introduction: Single incision laparoscopic surgery (SILS) is a common alternative to classical laparoscopic surgery. However, material costs of SILS significantly limit the spreading of this method to most of surgical departments in the Czech Republic. Therefore we introduced DILS, which is technically more difficult than 3- to 4-incision laparoscopy but comparable cost-wise and its result approaches the cosmetic effect of SILS.

NF-κB/p65 expression before and after treatment in rectal cancer patients undergoing neoadjuvant (chemo)radiotherapy and surgery: prognostic marker for disease progression and survival.

Nuclear factor-kappaB (NF-κB), especially p65 subunit, has been associated with origin and progression of cancer as well as with the resistance to radiotherapy and chemotherapy in experimental models. The aim of the present study was to determine expression of NF-κB/p65 in tumor specimens before and after treatment of rectal cancer patients and to evaluate possible relationship between expression of NF-κB/p65 before and after (chemo)radiotherapy, other tumor characteristics and the clinical outcome. Furthermore, NF-κB/p65 was studied in relationship to pathologic response to preoperative (chemo)radiotherapy.

Transient and Non-Transient Intussusceptions of the Large Bowel in Adults: Two Case Reports.

Background: Intussusception of the large bowel in adults is a very rare pathological condition. However, it has its clinical importance because intussusception is very often associated with an intraluminal lesion.

Case Report: We report two cases of the large bowel intussusception, ileocolic and colorectal.

Differential expression and processing of matrix metalloproteinase 19 marks progression of gastrointestinal diseases.

Matrix metalloproteinases (MMPs), responsible for extracellular matrix remodelling and processing of numerous soluble and cell-surface proteins, appear to play important roles in pathogenesis of gastrointestinal diseases. MMPs influence migration of inflammatory cells, mucosal destruction, matrix deposition and degradation. In this study, we analysed the expression of MMP-19 in the main forms of gastrointestinal diseases including inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease, and colorectal carcinoma.

[The NanoKnife and two successful cases of intracavitary irreversible electroporation of main bronchus tumours].

We have used the method of irreversible electroporation (IRE) twice to treat central non-small cell lung tumours. Both tumours obstructed the right main stem bronchus. Due to a high risk of right-sided pneumonectomy we chose to apply the tissue sparing device called NanoKnife and an alternative IRE method.

[Segmental duodenectomy (D3, D4) for angiosarcoma].

Unlabelled: A 66-year-old patient was admitted to the Department of Surgery at the Na Bulovce Hospital (First Faculty of Medicine, Charles University in Prague) following an episode of bleeding into the gastrointestinal tract. Gastroscopy found a large, wide-based sessile polypoid mass, exulcerated at its top and filling a major part of the intestinal lumen. Conclusion based on biopsy: malignant mesenchymal tumour - sarcoma.

[Single-incision thoracoscopic surgery--SITS].

Introduction: To report our initial experience with single-incision videothoracoscopic surgery.

Material And Methods: Between 2009 and 2011, we performed 31 operations using this approach. Neither intraoperatively nor postoperatively did we observe any complication related to the change in the surgical approach.

[Procedure on low extremities varicose veins using the VNUS-Closure radiofrequency ablation method].

From 01-06-2007 to 31-12-2008, the authors operated 334 patients with low extremities varicose veins, using the VNUS-Closure radiofrequency apparatus, in the surgical department of Príbram regional hospital (Oblastní nemocnice v Príbrami, a.s.).

[NF-kappaB, colorectal carcinoma and radiotherapy: results of a clinical and experimental study].

Resistance to radiotherapy often seen in rectal cancer patients requires intensive study of mechanisms taking part in this process. It seems that nuclear factor-kappaB (NF-kappaB), especially its subunit p65, could play an important role in radioresistance. The aims of this study were: 1.

[Surgeries for blunt and penetrating thoracic injuries].

Introduction: Up to 50% deaths due to fatal injuries result from thoracic injuries. Approximately 10-15 % of the injuries require thoracotomy.

Aim Of The Study: Indications and outcome of the surgery were assessed, based on the restrospective analysis data from subjects operated for blunt and penetrating thoracic injuries.

[Lung resection for a non-small cell carcinoma (stage IV) with a permanent intracavitary brachytherapy 125I].

In November 2005, the authors used the lung resection method in combination with peroperative brachytherapy125 for a non-small cell carcinoma, for the first time. The patient had an adenocarcinoma of the right lung T2N2M0, stage IIIA. During the procedure, the team diagnosed advanced stage of the process, the tumor originated in the hilus region of the middle lobe with a metastatic spread into the superior and inferior lobe.

[Contemporary approach to treatment of the posttraumatic empyema of the thorax].

Introduction: Empyema of the thorax is a serious morbidity and mortality causative factor in the postoperative period in severe blunt and penetrating thoracic injuries. The posttraumatic empyema of the thorax results, primarily, from secondary infections of the haemothorax. Current therapeutic management of the posttraumatic empyema of the thorax depends on the disease stage.

Apoptosis as an early event in the development of multiple organ failure?

We have recently developed a simple method of plasma free DNA detection, which enables us to distinguish between apoptotic and genomic (necrotic) DNA. After applying this method to the critically ill, we revealed apoptotic DNA on the day of admission to be higher than later when multiple-organ failure developed. Moreover, apoptotic DNA contributed to total plasma DNA much more than DNA from necrotic cells and its increase predicted future development of multiple-organ failure and death.

Bronchial myoplasty with the use of latissimus dorsi muscle--a case study.

Dehiscence of the bronchial stump as well as the tracheo-bronchial-pleural fistula is a rare but life-threatening complication of pulmonary resections. Absence of the immediately accessible well vascularized soft tissues makes successful direct resuture of the bronchial stump or local closure of the defect problematic, particularly in the infected terrain. The authors describe a case study of successful closure of the tracheo-bronchial defect with the use of pediculated latissimus dorsi muscle in a cachectic 63-year-old patient after a right-side pneumonectomy.

Higher content of 18:1 trans fatty acids in subcutaneous fat of persons with coronarographically documented atherosclerosis of the coronary arteries.

Aim: To identify the total content of trans fatty acid (TFA) isomers and C18:1 trans isomers in subcutaneous fat samples from persons with atherosclerosis of the coronary arteries, as an indicator of dietary exposure.

Methods: Using capillary gas chromatography, the authors determined total content of TFA isomers and C18:1 trans isomers in the subcutaneous fat of 34 patients with ischemic heart disease who had undergone aortocoronary bypass surgery and in 46 patients with no sign of coronary disease.

Results: On average, the total TFAs in cardiac patients were 2.