Publications by authors named "Fanru Yuan"
Article Synopsis
- - E76A mutations in SHP2 are linked to developmental diseases and cancers, and the inhibitor TNO155, which targets SHP2's allosteric site, is currently in clinical trials.
- - This study uses computational drug design to explore how TNO155 binds to SHP2, revealing it has a stronger binding affinity and unique dynamic interactions compared to another inhibitor, SHP099.
- - Findings indicate that specific residues in SHP2, particularly Arg111 and Glu250, enhance TNO155's binding through electrostatic interactions, and the E76A mutation further tightens this binding by increasing residue correlation and conformational fluctuations.
