Yishenyangsui granule for degenerative cervical myelopathy: a randomized, double-blind, placebo-controlled trial with long-term follow-up.

Objective: This randomized controlled trial aims to evaluate the efficacy and safety of Yishenyangsui granule for treating Degenerative Cervical Myelopathy.

Materials And Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted with 152 participants recruited from three centers and randomly assigned to receive either Yishenyangsui granule or placebo. The Japanese Orthopaedic Association (JOA) score and Neck Disability Index (NDI) score were evaluated for 32 weeks.

Synthesis and Structure of Pillar[]arene[1]phthalimide and Pillar[]arene[1]naphthalimide.

A series of monofunctionalized pillar[]arenes skeleton macrocycles pillar[]arene[1]phthalimide and pillar[]arene[1]naphthalimide ( = 4-6) were synthesized successfully through fragment coupling cyclization in a one-pot reaction. The introduction of pyromellitic diimide and naphthalene diimide units into the pillar[]arenes skeleton not only disturbs the symmetry of the pillar[]arenes but also changes their self-assembly behavior in the solid state. This functionalization approach greatly expands the structural diversity of the pillar[]arenes.

Pore blocking mechanisms of centipede toxin SsTx-4 on the inwardly rectifying potassium channels.

The peptide toxin SsTx-4 derived from venom of centipede Scolopendra subspinipes mutilans was characterized as a potent antagonist of the inwardly rectifying potassium (Kir) channel subtypes Kir1.1, Kir4.1, and Kir6.

Placental Barrier on Cadmium Transfer from Mother to Fetus in Related to Pregnancy Complications.

Purpose: As two of the most severe and common medical disorders during pregnancy, gestational diabetes mellitus (GDM) and hypertensive disorder complicating pregnancy (HDCP) cause adverse effects on placental barrier function and thus may lead to a high risk of intrauterine exposure to toxic metals from mother to fetus. This study investigates the impact of the placental barrier on the transfer of cadmium (Cd) from mother to fetus and the relationship between pregnancy complications.

Methods: A total of 107 pairs of samples were collected in Kunming, China; 29 were from healthy pregnant women, and 78 were from patients with pregnancy complications.

Pregnancy complications effect on the nickel content in maternal blood, placenta blood and umbilical cord blood during pregnancy.

Background: Nickel (Ni) may accumulate in the human body and has biological toxicity and carcinogenicity. Ni has an extensive impact on the health of pregnant women and fetuses during gestation.

Aim: To evaluate Ni exposure in pregnant women in Kunming, Yunnan Province, China; to describe the distribution of Ni in the maternal-fetal system and placental barrier function; and to investigate the effect of Ni exposure on fetal health in mothers with pregnancy complications.

Moxibustion treatment for primary osteoporosis: A systematic review of randomized controlled trials.

Primary osteoporosis (POP) has a serious impact on quality of life for middle-aged and elderly, which particularly increase the risk of fracture. We conducted the systematic review to evaluate the effects of moxibustion for POP in randomized controlled trials (RCTs).Eight databases were searched from their inception to July 30, 2016.