Publications by authors named "Fanny Steinbach"
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are severe inflammatory disorders that often involve focal necrotizing glomerulonephritis (FNGN) and consequent glomerular scarring, interstitial fibrosis, and chronic kidney disease. Robust murine models of scarring in FNGN that may help to further our understanding of deleterious processes are still lacking. Here, we present a murine model of severe FNGN based on combined administration of antibodies against the glomerular basement membrane (GBM) and myeloperoxidase (MPO), and bacterial lipopolysaccharides (LPS), that recapitulates acute injury and was adapted to investigate subsequent glomerular and interstitial scarring.
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- Radiotherapy is a common treatment for oral squamous cell carcinomas (OSCC), but it can also contribute to tumor relapse due to an immune-suppressive tumor microenvironment (TME).
- A new grafting model using a carcinogen-induced OSCC allows researchers to study the effects of radiotherapy on tumors while mirroring key features of human diseases, including mutations and immune cell infiltration.
- Findings show that while radiotherapy kills some tumor cells, it leaves behind a TME rich in tenascin-C (TNC), indicating immune suppression; surprising results show that tumors in TNC knockout hosts have less immune suppression and more tumor regression.