Publications by authors named "Fanny Mingant"
Article Synopsis
- Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder that can resemble type 1 or type 2A von Willebrand disease (VWD), but this case discusses whether it can also mimic type 2B VWD.
- A 64-year-old male patient displayed symptoms such as low platelet counts and reduced von Willebrand factor (VWF) activity, with testing showing an unexpected platelet reaction, which is typical for type 2B VWD; however, genetic tests did not support this diagnosis, suggesting AVWS instead.
- The case concludes that the AVWS was likely caused by a monoclonal immunoglobulin G antibody altering VWF structure, and for any surgical or bleeding situations, administering
Article Synopsis
- A study evaluated two D-dimer testing methods for diagnosing pulmonary embolism: VIDAS® and STA®-Liatest®.
- It involved 2530 patients and compared their sensitivity, specificity, and negative predictive value using fixed and age/fibrinogen-adjusted cutoff values.
- Results showed that both methods perform similarly, but using optimized cutoffs based on age and fibrinogen significantly boosts specificity without compromising sensitivity.
Article Synopsis
- Depuis 2013, le laboratoire d'hématologie du CHU de Brest utilise le dosage des monomères de fibrine pour détecter précocement l'activation de la coagulation et suivre l'évolution de la coagulation intravasculaire disséminée (CIVD).
- Cette méthode est complémentaire à celle des D-dimères et est utile dans divers contextes cliniques.
- Deux cas cliniques illustrent son importance : un cas d'hémorragie post-partum avec CIVD et un cas de placenta percreta, où les monomères de fibrine ont aidé à la détection et à la prise en charge des complications.
Background: An acute traumatic coagulopathy (ATC) is observed in about one third of severely traumatized patients. This early, specific, and endogenous disorder is triggered by the association of trauma and hemorrhage. The early phase of this condition is characterized by the expression of a bleeding phenotype leading to hemorrhagic shock and the late phase by a prothrombotic profile leading to multiple organ failure.
View Article and Find Full Text PDFWe report a very high factor V inhibitor affecting the measurement of all coagulation factors besides fibrinogen, all these factors being dramatically decreased. This inhibitor could be linked to antibiotic use. The patient died of massive hemorrhage before a plasma exchange could be initiated.
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- P2Y12 receptor inhibitors are used to prevent blood clots in patients with coronary artery disease, but high platelet reactivity can affect their effectiveness, which is often measured using the VASP-P assay.
- A study compared VASP-P with three other tests (LTA, MEA, and PFA) on 90 patients to assess their ability to evaluate platelet function, finding LTA closely matches VASP-P while MEA and PFA provide satisfactory results but may not completely replace it.
- Despite differences in time efficiency, all three tests can provide similar binary anti-aggregation results, indicating that if you're just looking for a yes/no answer on platelet function, they work comparably well.
We aimed to identify risk factors for recurrent venous thromboembolism (VTE) after unprovoked pulmonary embolism.Analyses were based on the double-blind randomised PADIS-PE trial, which included 371 patients with a first unprovoked pulmonary embolism initially treated during 6 months who were randomised to receive an additional 18 months of warfarin or placebo and followed up for 2 years after study treatment discontinuation. All patients had ventilation/perfusion lung scan at inclusion ( at 6 months of anticoagulation).
View Article and Find Full Text PDFEssential thrombocythemia (ET) and polycythemia vera (PV) are myeloproliferative neoplasms (MPN) with an increased risk of arterial and venous thrombosis. Aspirin is recommended to reduce this risk, but resistance to antiplatelet therapy seems to hamper its efficacy in some patients. We have previously shown that multiple electrode aggregometry (MEA) was a valuable tool to assess aspirin resistance in MPN.
View Article and Find Full Text PDFPurpose: Obese patients are known to be in an in vitro hypercoagulable state relative to normal-weight patients. Our study aimed to identify markers of enhanced coagulability (endogenous thrombin potential (ETP)) in morbidly obese patients using the thrombin generation (TG) test.
Materials And Methods: All patients scheduled for laparoscopic bariatric surgery (LBS) between September 1, 2014 and January 31, 2016 were eligible for our prospective study.
Reduction of coagulability state one year after bariatric surgery.
Surg Obes Relat Dis
February 2017
Background: Obese patients are in a hypercoagulable state relative to normal-weight patients. Low-grade inflammation may be a key factor for this condition.
Objectives: Our study aimed to compare the coagulability state of morbidly obese patients before and 1 year after bariatric surgery (BS) using the Thrombin Generation (TG) test, a validated method to assess coagulation in vitro.
Introduction: In myeloproliferative neoplasms (MPN), aspirin reduces the thrombotic risk. Nevertheless, aspirin resistance may be due to excessive platelet production ("turnover" resistance). Aspirin resistance can also result from a lack of effect of aspirin; this second component is called "intrinsic resistance".
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