Publications by authors named "Fanny Mazzamurro"
Natural transformation is the only mechanism of genetic exchange controlled by the recipient bacteria. We quantified its rates in 786 clinical strains of the human pathogens Legionella pneumophila (Lp) and 496 clinical and environmental strains of Acinetobacter baumannii (Ab). The analysis of transformation rates in the light of phylogeny revealed they evolve by a mixture of frequent small changes and a few large quick jumps across 6 orders of magnitude.
View Article and Find Full Text PDFThe opportunistic pathogen , carries variants of resistance islands (AbaR)-type genomic islands conferring multidrug resistance. Their pervasiveness in the species has remained enigmatic. The dissemination of AbaRs is intricately linked to their horizontal transfer via natural transformation, a process through which bacteria can import and recombine exogenous DNA, effecting allelic recombination, genetic acquisition, and deletion.
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- * A study on Escherichia coli revealed 60 gene groups that increase the likelihood of developing quinolone resistance through mutations in key genes, many of which are linked to various bacterial functions.
- * The research highlights that the interplay between horizontal gene transfer and mutations contributes to the rapid emergence of antibiotic resistance and potentially sets the stage for multidrug resistance in bacteria.